Vaccinia Virus Complement Control Protein Modulates Inflammation Following Spinal Cord Injury

D. N. Reynolds, S. A. Smith, Y. P. Zhang, D. K. Lahiri, D. J. Morassutti, C. B. Shields, G. J. Kotwal

Research output: Contribution to journalArticle

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Abstract

The vaccinia virus complement control protein (VCP) possesses multiple modulatory functions. Functioning as a complement inhibitory protein, VCP reduces production of proinflammatory chemotactic factors produced during complement activation. Additionally, VCP binds heparin and heparan sulfate proteoglycans, resulting in added functions shown to block monocyte chemotaxis in vitro. Using an in vivo spinal cord contusive injury model in rats, the inflammation-modulating abilities of VCP were evaluated. The results of both myeloperoxidase assaying and H&E stained section counts of spinal tissue reveal that neutrophll infiltration to the area of the lesion was reduced in animals that received VCP as compared to saline-injected controls.

Original languageEnglish (US)
Pages (from-to)534-539
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1010
DOIs
StatePublished - Jan 1 2003

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Keywords

  • Inflammation
  • Spinal cord injury
  • Vaccinia virus complement control protein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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