Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II

Yongxue Yao, Ping Li, Pratibha Singh, Allison T. Thiele, David S. Wilkes, Gourapura J. Renukaradhya, Randy Brutkiewicz, Jeffrey Travers, Gary D. Luker, Soon Cheol Hong, Janice Blum, Cheong Hee Chang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Vaccinia virus (VV) infection is known to inhibit dendritic cells (DC) functions in vitro. Paradoxically, VV is also highly immunogenic and thus has been used as a vaccine. In the present study, we investigated the effects of an in vivo VV infection on DC function by focusing on early innate immunity. Our data indicated that DC are activated upon in vivo VV infection of mice. Splenic DC from VV-infected mice expressed elevated levels of MHC class I and co-stimulatory molecules on their cell surface and exhibited the enhanced potential to produce cytokines upon LPS stimulation. DC from VV-infected mice also expressed a high level of interferon-β. However, a VV infection resulted in the down-regulation of MHC class II expression and the impairment of antigen presentation to CD4 T cells by DC. Thus, during the early stage of a VV infection, although DC are impaired in some of the critical antigen presentation functions, they can promote innate immune defenses against viral infection.

Original languageEnglish
Pages (from-to)92-102
Number of pages11
JournalCellular Immunology
Volume246
Issue number2
DOIs
StatePublished - Apr 2007

Fingerprint

Vaccinia virus
Antigen Presentation
Virus Diseases
Dendritic Cells
Innate Immunity
Interferons
Down-Regulation
Vaccines
Cytokines
T-Lymphocytes

Keywords

  • Cytokines
  • Dendritic cell
  • Gene regulation
  • Innate immunity
  • MHC class II
  • Type I interferon
  • Vaccinia virus

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Yao, Y., Li, P., Singh, P., Thiele, A. T., Wilkes, D. S., Renukaradhya, G. J., ... Chang, C. H. (2007). Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II. Cellular Immunology, 246(2), 92-102. https://doi.org/10.1016/j.cellimm.2007.06.005

Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II. / Yao, Yongxue; Li, Ping; Singh, Pratibha; Thiele, Allison T.; Wilkes, David S.; Renukaradhya, Gourapura J.; Brutkiewicz, Randy; Travers, Jeffrey; Luker, Gary D.; Hong, Soon Cheol; Blum, Janice; Chang, Cheong Hee.

In: Cellular Immunology, Vol. 246, No. 2, 04.2007, p. 92-102.

Research output: Contribution to journalArticle

Yao, Y, Li, P, Singh, P, Thiele, AT, Wilkes, DS, Renukaradhya, GJ, Brutkiewicz, R, Travers, J, Luker, GD, Hong, SC, Blum, J & Chang, CH 2007, 'Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II', Cellular Immunology, vol. 246, no. 2, pp. 92-102. https://doi.org/10.1016/j.cellimm.2007.06.005
Yao, Yongxue ; Li, Ping ; Singh, Pratibha ; Thiele, Allison T. ; Wilkes, David S. ; Renukaradhya, Gourapura J. ; Brutkiewicz, Randy ; Travers, Jeffrey ; Luker, Gary D. ; Hong, Soon Cheol ; Blum, Janice ; Chang, Cheong Hee. / Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II. In: Cellular Immunology. 2007 ; Vol. 246, No. 2. pp. 92-102.
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