Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET

O. Muzik, R. S.B. Beanlands, G. D. Hutchins, T. J. Mangner, N. Nguyen, M. Schwaiger

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229 Scopus citations

Abstract

Positron emission tomography has been shown to provide quantitative estimates of myocardial blood flow using 13N-ammonia and 15O-water. In a validation study, myocardial blood flow was noninvasively determined in 11 open-chest anesthetized dogs using dynamic positron emission tomography. The radiopharmaceuticals 13N-ammonia and 15O-water were intravenously administered and measurements were carried out at rest and following pharmacological vasodilation to assess blood flow over a range from 53 to 580 ml/100 g/min. Quantification of blood flow based on tracer kinetic modeling of 13N-ammonia data correlated closely with myocardial blood flow determined by microspheres (y = 0.944 x +7.22, r = 0.986) and with the 15O- water injection technique y = 1.054 x -15.8 (r = 0.99). The use of 13N- ammonia with positron emission tomography enables the accurate quantification of myocardial blood flow. Using this technique, uncomplicated study protocols simplify the measurement procedures while providing excellent qualitative and quantitative information.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalJournal of Nuclear Medicine
Volume34
Issue number1
StatePublished - 1993

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Muzik, O., Beanlands, R. S. B., Hutchins, G. D., Mangner, T. J., Nguyen, N., & Schwaiger, M. (1993). Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET. Journal of Nuclear Medicine, 34(1), 83-91.