Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy

Peter W. Choo, Cynthia S. Rańd, Thomas Inui, Mei Ling T Lee, Emily Cain, Michelle Cordeiro-Breault, Claire Canning, Richard Platt

Research output: Contribution to journalArticle

448 Citations (Scopus)

Abstract

OBJECTIVES. To evaluate the validity of patient report, pharmacy dispensing records, and pill counts as measures of antihypertensive adherence using electronic monitoring as the validation standard. METHODS. The study was conducted among 286 members of Harvard Pilgrim Health Care, a managed care organization, who were at least 18 years of age, on monotherapy for hypertension, and had prescription drug coverage. Prescription refill adherence during the 12 months before enrollment was determined from their automated pharmacy dispensing records. Participants were interviewed about their medication adherence before and after a 3-month electronic monitoring period during which pill counts were also performed. Adherence to both recommended number and timing of doses was estimated from electronic monitoring data. Data analysis was based on statistical correlation and analysis of variance. RESULTS. Electronic adherence monitoring revealed that the proportion of prescribed doses consumed was higher (0.92) than the proportion of doses taken on time (0.63). The correlation between adherence to quantity and timing of doses was 0.32. Concurrent pill counts and earlier refilling patterns were moderately correlated with electronic monitoring (pill count: r = .52 with quantity and r = .17 with timing; refill adherence r = .32 with quantity and r = .22 with timing). There was considerable misclassification of adherence reported by patients, although nonadherence was generally accurately reported. CONCLUSIONS. Deviation from recommended timing of doses appears to be greater than from prescribed number of doses. Pharmacy dispensing records demonstrate predictive validity as measures of cumulative exposure and gaps in medication supply. Adherence levels determined from pill counts and pharmacy dispensing records correlate more closely with quantity than with riming of doses. Nonadherence reported by patients can serve as a qualitative indicator and predictor of reduced adherence.

Original languageEnglish (US)
Pages (from-to)846-857
Number of pages12
JournalMedical Care
Volume37
Issue number9
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Antihypertensive Agents
electronics
monitoring
medication
Patient Compliance
Medication Adherence
Prescription Drugs
Managed Care Programs
Therapeutics
Prescriptions
hypertension
Analysis of Variance
analysis of variance
managed care
Organizations
Hypertension
Delivery of Health Care
data analysis
coverage
health care

Keywords

  • Adherence
  • Antihypertensive therapy
  • Automated pharmacy records
  • Electronic adherence monitoring
  • Measurement validation
  • Pill counts

ASJC Scopus subject areas

  • Nursing(all)
  • Public Health, Environmental and Occupational Health
  • Health(social science)
  • Health Professions(all)

Cite this

Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy. / Choo, Peter W.; Rańd, Cynthia S.; Inui, Thomas; Lee, Mei Ling T; Cain, Emily; Cordeiro-Breault, Michelle; Canning, Claire; Platt, Richard.

In: Medical Care, Vol. 37, No. 9, 1999, p. 846-857.

Research output: Contribution to journalArticle

Choo, Peter W. ; Rańd, Cynthia S. ; Inui, Thomas ; Lee, Mei Ling T ; Cain, Emily ; Cordeiro-Breault, Michelle ; Canning, Claire ; Platt, Richard. / Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy. In: Medical Care. 1999 ; Vol. 37, No. 9. pp. 846-857.
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AU - Choo, Peter W.

AU - Rańd, Cynthia S.

AU - Inui, Thomas

AU - Lee, Mei Ling T

AU - Cain, Emily

AU - Cordeiro-Breault, Michelle

AU - Canning, Claire

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AB - OBJECTIVES. To evaluate the validity of patient report, pharmacy dispensing records, and pill counts as measures of antihypertensive adherence using electronic monitoring as the validation standard. METHODS. The study was conducted among 286 members of Harvard Pilgrim Health Care, a managed care organization, who were at least 18 years of age, on monotherapy for hypertension, and had prescription drug coverage. Prescription refill adherence during the 12 months before enrollment was determined from their automated pharmacy dispensing records. Participants were interviewed about their medication adherence before and after a 3-month electronic monitoring period during which pill counts were also performed. Adherence to both recommended number and timing of doses was estimated from electronic monitoring data. Data analysis was based on statistical correlation and analysis of variance. RESULTS. Electronic adherence monitoring revealed that the proportion of prescribed doses consumed was higher (0.92) than the proportion of doses taken on time (0.63). The correlation between adherence to quantity and timing of doses was 0.32. Concurrent pill counts and earlier refilling patterns were moderately correlated with electronic monitoring (pill count: r = .52 with quantity and r = .17 with timing; refill adherence r = .32 with quantity and r = .22 with timing). There was considerable misclassification of adherence reported by patients, although nonadherence was generally accurately reported. CONCLUSIONS. Deviation from recommended timing of doses appears to be greater than from prescribed number of doses. Pharmacy dispensing records demonstrate predictive validity as measures of cumulative exposure and gaps in medication supply. Adherence levels determined from pill counts and pharmacy dispensing records correlate more closely with quantity than with riming of doses. Nonadherence reported by patients can serve as a qualitative indicator and predictor of reduced adherence.

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KW - Measurement validation

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