Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsy

Anees Chagpar, Robert C. Martin, Celia Chao, Sandra L. Wong, Michael J. Edwards, Todd Tuttle, Kelly M. McMasters, Nora M. Hansen, Howard Silberman, Gary B. Talpos, Anton Joel Bilchick, Mary C. McCarthy, C. Schmidt, James E. Goodnight

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Hypothesis: Subareolar or periareolar injection of radioactive technetium sulfur colloid is equivalent to other injection techniques for breast cancer sentinel lymph node (SLN) biopsy. Design and Setting: Prospective, multicenter clinical trial. Patients: A total of 3961 individuals with clinical stage I and II breast cancer. Interventions: All patients underwent attempted SLN biopsy followed by completion axillary dissection. Injection technique was determined by the preference of each participating surgeon. Most surgeons had little or no experience with SLN biopsy before participation in this study. Main Outcome Measures: The SLN identification and false-negative rates. Results: An SLN biopsy was performed in 3961 patients using blue dye alone or radioactive colloid plus blue dye. Subareolar and periareolar radioactive colloid injection techniques were associated with SLN identification rates of 99.3% and 95.6%, respectively, with false-negative rates of 8.3% and 8.9%, respectively. The identification rates were significantly higher for these 2 techniques than for peritumoral injection of radioactive colloid (91.1%) or the use of blue dye alone (88.5%) (P

Original languageEnglish (US)
Pages (from-to)614-620
Number of pages7
JournalArchives of Surgery
Volume139
Issue number6
DOIs
StatePublished - Jun 2004
Externally publishedYes

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Sentinel Lymph Node Biopsy
Breast
Colloids
Injections
Coloring Agents
Technetium Tc 99m Sulfur Colloid
Breast Neoplasms
Multicenter Studies
Dissection
Outcome Assessment (Health Care)
Clinical Trials

ASJC Scopus subject areas

  • Surgery

Cite this

Chagpar, A., Martin, R. C., Chao, C., Wong, S. L., Edwards, M. J., Tuttle, T., ... Goodnight, J. E. (2004). Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsy. Archives of Surgery, 139(6), 614-620. https://doi.org/10.1001/archsurg.139.6.614

Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsy. / Chagpar, Anees; Martin, Robert C.; Chao, Celia; Wong, Sandra L.; Edwards, Michael J.; Tuttle, Todd; McMasters, Kelly M.; Hansen, Nora M.; Silberman, Howard; Talpos, Gary B.; Bilchick, Anton Joel; McCarthy, Mary C.; Schmidt, C.; Goodnight, James E.

In: Archives of Surgery, Vol. 139, No. 6, 06.2004, p. 614-620.

Research output: Contribution to journalArticle

Chagpar, A, Martin, RC, Chao, C, Wong, SL, Edwards, MJ, Tuttle, T, McMasters, KM, Hansen, NM, Silberman, H, Talpos, GB, Bilchick, AJ, McCarthy, MC, Schmidt, C & Goodnight, JE 2004, 'Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsy', Archives of Surgery, vol. 139, no. 6, pp. 614-620. https://doi.org/10.1001/archsurg.139.6.614
Chagpar, Anees ; Martin, Robert C. ; Chao, Celia ; Wong, Sandra L. ; Edwards, Michael J. ; Tuttle, Todd ; McMasters, Kelly M. ; Hansen, Nora M. ; Silberman, Howard ; Talpos, Gary B. ; Bilchick, Anton Joel ; McCarthy, Mary C. ; Schmidt, C. ; Goodnight, James E. / Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsy. In: Archives of Surgery. 2004 ; Vol. 139, No. 6. pp. 614-620.
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