Objective: Evaluate the reliability and validity of the Kidney Disease Quality of Life Short Form 36 (KDQOL-36™) in Hispanics with mild-tomoderate chronic kidney disease (CKD). Design: Cross-sectional Setting: Chronic Renal Insufficiency Cohort Study Participants: 420 Hispanic (150 English- and 270 Spanish-speakers), and 409 non-Hispanic White individuals, matched by age (mean 57 years), sex (60% male), kidney function (mean estimated glomerular filtration rate 36ml/min/1.73m2), and diabetes (70%). Methods: To measure construct validity, we selected instruments, comorbidities, and laboratory tests related to at least one KDQOL-36™ subscale. Reliability was determined by calculating Cronbach's alpha. Results: Reliability of each KDQOL-36™ subscale [SF-12 Physical Component Summary (PCS) and Mental Component Summary (MCS), Symptoms/Problems, Burden of Kidney Disease and Effects of Kidney Disease] was very good (Cronbach's alpha >0.8). Construct validity was supported by expected negative correlation between MCS scores and the Beck Depression Inventory in all three subgroups (r= 20.56 to 20.61, P, <0001). There was inverse correlation between the Symptoms/Problems subscale and the Patient Symptom Form (r= 20.70 to 20.77, P,<0001). We also found significant, positive correlation between the PCS score and a physical activity survey (r= +0.29 to +0.38, P≤.003); and between the PCS and MCS scores and the Kansas City Questionnaire (r= +0.31 to +0.64, P,<0001). Reliability and validity were similar across all racial/ethnic groups analyzed separately. Conclusion: Our findings support the use of the KDQOL-36™ as a measure of HRQOL in this cohort of US Hispanics with CKD.
|Original language||English (US)|
|Number of pages||8|
|Journal||Ethnicity and Disease|
|State||Published - Mar 1 2013|
- Quality of Life
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