Validation of the Kidney Disease Quality of Life Short Form 36 (KDQOL-36™) US Spanish and English versions in a cohort of Hispanics with chronic kidney disease

Ana C. Ricardo, Eileen Hacker, Claudia M. Lora, Lynn Ackerson, Karen B. De Salvo, Alan Go, John W. Kusek, Lisa Nessel, Akinlolu Ojo, Raymond R. Townsend, Dawei Xie, Carol E. Ferrans, James P. Lash

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Objective: Evaluate the reliability and validity of the Kidney Disease Quality of Life Short Form 36 (KDQOL-36™) in Hispanics with mild-tomoderate chronic kidney disease (CKD). Design: Cross-sectional Setting: Chronic Renal Insufficiency Cohort Study Participants: 420 Hispanic (150 English- and 270 Spanish-speakers), and 409 non-Hispanic White individuals, matched by age (mean 57 years), sex (60% male), kidney function (mean estimated glomerular filtration rate 36ml/min/1.73m2), and diabetes (70%). Methods: To measure construct validity, we selected instruments, comorbidities, and laboratory tests related to at least one KDQOL-36™ subscale. Reliability was determined by calculating Cronbach's alpha. Results: Reliability of each KDQOL-36™ subscale [SF-12 Physical Component Summary (PCS) and Mental Component Summary (MCS), Symptoms/Problems, Burden of Kidney Disease and Effects of Kidney Disease] was very good (Cronbach's alpha >0.8). Construct validity was supported by expected negative correlation between MCS scores and the Beck Depression Inventory in all three subgroups (r= 20.56 to 20.61, P, <0001). There was inverse correlation between the Symptoms/Problems subscale and the Patient Symptom Form (r= 20.70 to 20.77, P,<0001). We also found significant, positive correlation between the PCS score and a physical activity survey (r= +0.29 to +0.38, P≤.003); and between the PCS and MCS scores and the Kansas City Questionnaire (r= +0.31 to +0.64, P,<0001). Reliability and validity were similar across all racial/ethnic groups analyzed separately. Conclusion: Our findings support the use of the KDQOL-36™ as a measure of HRQOL in this cohort of US Hispanics with CKD.

Original languageEnglish (US)
Pages (from-to)202-209
Number of pages8
JournalEthnicity and Disease
Volume23
Issue number2
StatePublished - Mar 1 2013
Externally publishedYes

Keywords

  • Hispanics
  • Quality of Life
  • Validation

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Validation of the Kidney Disease Quality of Life Short Form 36 (KDQOL-36™) US Spanish and English versions in a cohort of Hispanics with chronic kidney disease'. Together they form a unique fingerprint.

  • Cite this

    Ricardo, A. C., Hacker, E., Lora, C. M., Ackerson, L., De Salvo, K. B., Go, A., Kusek, J. W., Nessel, L., Ojo, A., Townsend, R. R., Xie, D., Ferrans, C. E., & Lash, J. P. (2013). Validation of the Kidney Disease Quality of Life Short Form 36 (KDQOL-36™) US Spanish and English versions in a cohort of Hispanics with chronic kidney disease. Ethnicity and Disease, 23(2), 202-209.