Variant apolipoprotein AI as a major constituent of a human hereditary amyloid

William C. Nichols, Francis E. Dwulet, Juris Liepnieks, Merrill D. Benson

Research output: Contribution to journalArticle

182 Scopus citations

Abstract

Amyloid fibrils were isolated from spleen and liver of a patient who died with Familial Amyloidotic Polyneuropathy Type III (Iowa). The major protein constituent of the fibrils was found to be the amino terminal portion (residues 1-83) of apolipoprotein AI with an arginine for glycine substitution at position 26. This is the first report of an apolipoprotein as a major amyloid constituent in a form of autosomal dominant hereditary amyloidosis in humans.

Original languageEnglish (US)
Pages (from-to)762-768
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume156
Issue number2
DOIs
StatePublished - Oct 31 1988

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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