Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels

for the Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

Abstract

Background: CCL16 is a chemokine predominantly expressed in the liver, but is also found in the blood and brain, and is known to play important roles in immune response and angiogenesis. Little is known about the gene's regulation. Methods: Here, we test for potential causal SNPs that affect CCL16 protein levels in both blood plasma and cerebrospinal fluid in a genome-wide association study across two datasets. We then use METAL to performed meta-analyses with a significance threshold of p 5x10-8. We removed SNPs where the direction of the effect was different between the two datasets. Results: We identify 10 SNPs associated with increased CCL16 protein levels in both biological fluids. Conclusions: Our results will help understand CCL16's regulation, allowing researchers to better understand the gene's effects on human health.

Original languageEnglish (US)
Article number437
JournalBMC Genomics
Volume17
DOIs
StatePublished - Jun 29 2016

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Cerebrospinal Fluid Proteins
Single Nucleotide Polymorphism
Genome-Wide Association Study
Chemokines
Genes
Cerebrospinal Fluid
Meta-Analysis
Proteins
Research Personnel
Liver
Health
Brain
Datasets

Keywords

  • Association
  • Blood
  • Brain
  • CCL16
  • Cerebrospinal fluid
  • Genetics
  • Plasma

ASJC Scopus subject areas

  • Biotechnology
  • Genetics

Cite this

Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels. / for the Alzheimer's Disease Neuroimaging Initiative.

In: BMC Genomics, Vol. 17, 437, 29.06.2016.

Research output: Contribution to journalArticle

for the Alzheimer's Disease Neuroimaging Initiative. / Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels. In: BMC Genomics. 2016 ; Vol. 17.
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AU - Ebbert, Mark T W

AU - Staley, Lyndsay A.

AU - Parker, Joshua

AU - Parker, Sheradyn

AU - Bailey, Matthew

AU - Weiner, Michael

AU - Aisen, Paul

AU - Petersen, Ronald

AU - Jack, Clifford R.

AU - Jagust, William

AU - Trojanowki, John Q.

AU - Toga, Arthur W.

AU - Beckett, Laurel

AU - Green, Robert C.

AU - Saykin, Andrew

AU - Morris, John

AU - Ridge, Perry G.

AU - Goate, Alison M.

AU - Kauwe, John S K

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