Variation in the ADH1B proximal promoter affects expression

Sirisha Pochareddy, Howard J. Edenberg

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The primary pathway of metabolism of dietary alcohol is via its oxidation in liver by alcohol dehydrogenases (ADH). Differences in the ADH enzyme activity or levels of enzyme present could affect the risk for alcoholism. Regulatory variations have been shown to affect the promoter activity and thereby affect the risk for alcoholism. In this study the functional effects of the two SNPs (rs1159918 and rs1229982) in the proximal promoter region of ADH1B that were associated with alcoholism were explored. We examined the effects of five naturally occurring haplotypes on the promoter activity. We observed that a C to A change at rs1229982 increased promoter activity 1.4-fold.

Original languageEnglish (US)
Pages (from-to)38-41
Number of pages4
JournalChemico-Biological Interactions
Volume191
Issue number1-3
DOIs
StatePublished - May 30 2011

Keywords

  • Alcohol dehydrogenase 1B
  • Alcoholism
  • Gene expression
  • Haplotype
  • Polymorphism
  • Promoter
  • SNP

ASJC Scopus subject areas

  • Toxicology

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