Varying influences of aldosterone on the plasma potassium concentration in blacks and whites

Wanzhu Tu, George J. Eckert, Brian Decker, John Howard Pratt

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND Aldosterone acts to restrain the extracellular potassium (K+) concentration. Blacks have on average lower plasma aldosterone concentrations (PACs) than Whites. Whether this ethnic difference is associated with similar changes in the concentration of K+ is unclear. METHODS Subjects were Blacks and Whites from an observational study of blood pressure regulation. PAC was known to be significantly lower in Blacks than Whites. We sought to test the hypothesis that the concentration of K+ remains constant despite variability in PAC. Initial enrollment took place in childhood in 1986. Some of the original enrollees were studied again in adulthood: 160 healthy Blacks and 271 healthy Whites (ages 5 to 39 years; all were studied as children and as adults). RESULTS Plasma renin activity [a biomarker of angiotensin II and, more proximally, extracellular fluid volume (ECFV)] and PAC were lower in Blacks (P < 0.0354 and P < 0.001, respectively, for all ages). At the same time no ethnic difference in levels of K+ was observed regardless of age. Plasma K+ concentration and PAC associated differently based on ethnicity: PAC increased in Blacks by 1.5-2.0 and in Whites by 2.3-3.0 ng/dl per mmol/l increase in K+ (P < 0.001). CONCLUSIONS Lower aldosterone levels in Blacks did not translate into higher K+ concentrations. We speculate that reaching the right concentration of K+ was an endpoint of aldosterone production in the presence of varying levels of ECFV and angiotensin II.

Original languageEnglish (US)
Pages (from-to)490-494
Number of pages5
JournalAmerican Journal of Hypertension
Volume30
Issue number5
DOIs
StatePublished - 2017

Fingerprint

Aldosterone
Potassium
Extracellular Fluid
Angiotensin II
hydroquinone
Plasma Volume
Renin
Observational Studies
Biomarkers
Blood Pressure

Keywords

  • aldosterone
  • angiotensin II, blood pressure
  • ethnicity
  • extracellular fluid volume
  • hypertension
  • potassium

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Varying influences of aldosterone on the plasma potassium concentration in blacks and whites. / Tu, Wanzhu; Eckert, George J.; Decker, Brian; Pratt, John Howard.

In: American Journal of Hypertension, Vol. 30, No. 5, 2017, p. 490-494.

Research output: Contribution to journalArticle

@article{0c98c23c995f496a933ecb3be32f4f86,
title = "Varying influences of aldosterone on the plasma potassium concentration in blacks and whites",
abstract = "BACKGROUND Aldosterone acts to restrain the extracellular potassium (K+) concentration. Blacks have on average lower plasma aldosterone concentrations (PACs) than Whites. Whether this ethnic difference is associated with similar changes in the concentration of K+ is unclear. METHODS Subjects were Blacks and Whites from an observational study of blood pressure regulation. PAC was known to be significantly lower in Blacks than Whites. We sought to test the hypothesis that the concentration of K+ remains constant despite variability in PAC. Initial enrollment took place in childhood in 1986. Some of the original enrollees were studied again in adulthood: 160 healthy Blacks and 271 healthy Whites (ages 5 to 39 years; all were studied as children and as adults). RESULTS Plasma renin activity [a biomarker of angiotensin II and, more proximally, extracellular fluid volume (ECFV)] and PAC were lower in Blacks (P < 0.0354 and P < 0.001, respectively, for all ages). At the same time no ethnic difference in levels of K+ was observed regardless of age. Plasma K+ concentration and PAC associated differently based on ethnicity: PAC increased in Blacks by 1.5-2.0 and in Whites by 2.3-3.0 ng/dl per mmol/l increase in K+ (P < 0.001). CONCLUSIONS Lower aldosterone levels in Blacks did not translate into higher K+ concentrations. We speculate that reaching the right concentration of K+ was an endpoint of aldosterone production in the presence of varying levels of ECFV and angiotensin II.",
keywords = "aldosterone, angiotensin II, blood pressure, ethnicity, extracellular fluid volume, hypertension, potassium",
author = "Wanzhu Tu and Eckert, {George J.} and Brian Decker and Pratt, {John Howard}",
year = "2017",
doi = "10.1093/ajh/hpx006",
language = "English (US)",
volume = "30",
pages = "490--494",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Varying influences of aldosterone on the plasma potassium concentration in blacks and whites

AU - Tu, Wanzhu

AU - Eckert, George J.

AU - Decker, Brian

AU - Pratt, John Howard

PY - 2017

Y1 - 2017

N2 - BACKGROUND Aldosterone acts to restrain the extracellular potassium (K+) concentration. Blacks have on average lower plasma aldosterone concentrations (PACs) than Whites. Whether this ethnic difference is associated with similar changes in the concentration of K+ is unclear. METHODS Subjects were Blacks and Whites from an observational study of blood pressure regulation. PAC was known to be significantly lower in Blacks than Whites. We sought to test the hypothesis that the concentration of K+ remains constant despite variability in PAC. Initial enrollment took place in childhood in 1986. Some of the original enrollees were studied again in adulthood: 160 healthy Blacks and 271 healthy Whites (ages 5 to 39 years; all were studied as children and as adults). RESULTS Plasma renin activity [a biomarker of angiotensin II and, more proximally, extracellular fluid volume (ECFV)] and PAC were lower in Blacks (P < 0.0354 and P < 0.001, respectively, for all ages). At the same time no ethnic difference in levels of K+ was observed regardless of age. Plasma K+ concentration and PAC associated differently based on ethnicity: PAC increased in Blacks by 1.5-2.0 and in Whites by 2.3-3.0 ng/dl per mmol/l increase in K+ (P < 0.001). CONCLUSIONS Lower aldosterone levels in Blacks did not translate into higher K+ concentrations. We speculate that reaching the right concentration of K+ was an endpoint of aldosterone production in the presence of varying levels of ECFV and angiotensin II.

AB - BACKGROUND Aldosterone acts to restrain the extracellular potassium (K+) concentration. Blacks have on average lower plasma aldosterone concentrations (PACs) than Whites. Whether this ethnic difference is associated with similar changes in the concentration of K+ is unclear. METHODS Subjects were Blacks and Whites from an observational study of blood pressure regulation. PAC was known to be significantly lower in Blacks than Whites. We sought to test the hypothesis that the concentration of K+ remains constant despite variability in PAC. Initial enrollment took place in childhood in 1986. Some of the original enrollees were studied again in adulthood: 160 healthy Blacks and 271 healthy Whites (ages 5 to 39 years; all were studied as children and as adults). RESULTS Plasma renin activity [a biomarker of angiotensin II and, more proximally, extracellular fluid volume (ECFV)] and PAC were lower in Blacks (P < 0.0354 and P < 0.001, respectively, for all ages). At the same time no ethnic difference in levels of K+ was observed regardless of age. Plasma K+ concentration and PAC associated differently based on ethnicity: PAC increased in Blacks by 1.5-2.0 and in Whites by 2.3-3.0 ng/dl per mmol/l increase in K+ (P < 0.001). CONCLUSIONS Lower aldosterone levels in Blacks did not translate into higher K+ concentrations. We speculate that reaching the right concentration of K+ was an endpoint of aldosterone production in the presence of varying levels of ECFV and angiotensin II.

KW - aldosterone

KW - angiotensin II, blood pressure

KW - ethnicity

KW - extracellular fluid volume

KW - hypertension

KW - potassium

UR - http://www.scopus.com/inward/record.url?scp=85021799702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021799702&partnerID=8YFLogxK

U2 - 10.1093/ajh/hpx006

DO - 10.1093/ajh/hpx006

M3 - Article

C2 - 28338830

AN - SCOPUS:85021799702

VL - 30

SP - 490

EP - 494

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 5

ER -