Vascular calcification: Pathophysiology and risk factors

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Vascular calcification can occur in nearly all arterial beds and in both the medial and intimal layers. The initiating factors and clinical consequences depend on the underlying disease state and location of the calcification. The best studied manifestation is coronary artery calcification, in part because of the obvious clinical consequences, but also because of CT-based imaging modalities. In the general population, the presence of coronary artery calcification increases cardiovascular risk above that predicted by traditional Framingham risk factors, suggesting the presence of nontraditional risk factors. In patients with chronic kidney disease (CKD), coronary artery calcification is more prevalent and markedly more severe than in the general population. In these CKD patients, nontraditional risk factors such as oxidative stress, advanced glycation end products, and disordered mineral metabolism are also more prevalent and more severe and offer mechanistic insight into the pathogenesis of vascular calcification.

Original languageEnglish
Pages (from-to)228-237
Number of pages10
JournalCurrent Hypertension Reports
Volume14
Issue number3
DOIs
StatePublished - Jun 2012

Fingerprint

Vascular Calcification
Coronary Vessels
Chronic Renal Insufficiency
Tunica Intima
Advanced Glycosylation End Products
Population
Minerals
Oxidative Stress

Keywords

  • Chronic kidney disease (CKD)
  • Diabetes
  • Hypertension
  • Nontraditional risk factors
  • Traditional risk factors
  • Vascular calcification

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Vascular calcification : Pathophysiology and risk factors. / Chen, Xuening (Neal); Moe, Sharon.

In: Current Hypertension Reports, Vol. 14, No. 3, 06.2012, p. 228-237.

Research output: Contribution to journalArticle

@article{e09a9a7e3b9146a9a287332a62aeac48,
title = "Vascular calcification: Pathophysiology and risk factors",
abstract = "Vascular calcification can occur in nearly all arterial beds and in both the medial and intimal layers. The initiating factors and clinical consequences depend on the underlying disease state and location of the calcification. The best studied manifestation is coronary artery calcification, in part because of the obvious clinical consequences, but also because of CT-based imaging modalities. In the general population, the presence of coronary artery calcification increases cardiovascular risk above that predicted by traditional Framingham risk factors, suggesting the presence of nontraditional risk factors. In patients with chronic kidney disease (CKD), coronary artery calcification is more prevalent and markedly more severe than in the general population. In these CKD patients, nontraditional risk factors such as oxidative stress, advanced glycation end products, and disordered mineral metabolism are also more prevalent and more severe and offer mechanistic insight into the pathogenesis of vascular calcification.",
keywords = "Chronic kidney disease (CKD), Diabetes, Hypertension, Nontraditional risk factors, Traditional risk factors, Vascular calcification",
author = "Chen, {Xuening (Neal)} and Sharon Moe",
year = "2012",
month = "6",
doi = "10.1007/s11906-012-0265-8",
language = "English",
volume = "14",
pages = "228--237",
journal = "Current Hypertension Reports",
issn = "1522-6417",
publisher = "Current Medicine Group",
number = "3",

}

TY - JOUR

T1 - Vascular calcification

T2 - Pathophysiology and risk factors

AU - Chen, Xuening (Neal)

AU - Moe, Sharon

PY - 2012/6

Y1 - 2012/6

N2 - Vascular calcification can occur in nearly all arterial beds and in both the medial and intimal layers. The initiating factors and clinical consequences depend on the underlying disease state and location of the calcification. The best studied manifestation is coronary artery calcification, in part because of the obvious clinical consequences, but also because of CT-based imaging modalities. In the general population, the presence of coronary artery calcification increases cardiovascular risk above that predicted by traditional Framingham risk factors, suggesting the presence of nontraditional risk factors. In patients with chronic kidney disease (CKD), coronary artery calcification is more prevalent and markedly more severe than in the general population. In these CKD patients, nontraditional risk factors such as oxidative stress, advanced glycation end products, and disordered mineral metabolism are also more prevalent and more severe and offer mechanistic insight into the pathogenesis of vascular calcification.

AB - Vascular calcification can occur in nearly all arterial beds and in both the medial and intimal layers. The initiating factors and clinical consequences depend on the underlying disease state and location of the calcification. The best studied manifestation is coronary artery calcification, in part because of the obvious clinical consequences, but also because of CT-based imaging modalities. In the general population, the presence of coronary artery calcification increases cardiovascular risk above that predicted by traditional Framingham risk factors, suggesting the presence of nontraditional risk factors. In patients with chronic kidney disease (CKD), coronary artery calcification is more prevalent and markedly more severe than in the general population. In these CKD patients, nontraditional risk factors such as oxidative stress, advanced glycation end products, and disordered mineral metabolism are also more prevalent and more severe and offer mechanistic insight into the pathogenesis of vascular calcification.

KW - Chronic kidney disease (CKD)

KW - Diabetes

KW - Hypertension

KW - Nontraditional risk factors

KW - Traditional risk factors

KW - Vascular calcification

UR - http://www.scopus.com/inward/record.url?scp=84865688452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865688452&partnerID=8YFLogxK

U2 - 10.1007/s11906-012-0265-8

DO - 10.1007/s11906-012-0265-8

M3 - Article

C2 - 22476974

AN - SCOPUS:84865688452

VL - 14

SP - 228

EP - 237

JO - Current Hypertension Reports

JF - Current Hypertension Reports

SN - 1522-6417

IS - 3

ER -