Vascular Dysfunction in Diabetes and Glaucoma: A Complex Relationship Reviewed

Austin L. Gerber, Alon Harris, Brent Siesky, Eric Lee, Tara J. Schaab, Andrew Huck, Annahita Amireskandari

Research output: Contribution to journalReview article

13 Scopus citations


Open-angle glaucoma (OAG) is a multifactorial disease characterized by progressive retinal ganglion cell death and visual field loss. Intraocular pressure, ocular perfusion pressure, and systemic vascular irregularities have all been identified as contributing factors for glaucoma onset and progression. Focal and systemic vascular abnormalities have also been well documented in diabetic patients. The relationship between diabetes mellitus and OAG remains enigmatic in the literature. As the pathogenesis of both diabetes mellitus and OAG involves compromised vascular regulation, this review was undertaken to further investigate their precise relationship. A literature review of published population-based studies was performed, with a focus on studies regarding blood flow abnormalities. Although current studies support the role of vascular contributions to both diseases, the association between glaucoma and diabetes yields contrasting results.

Original languageEnglish (US)
Pages (from-to)474-479
Number of pages6
JournalJournal of Glaucoma
Issue number6
StatePublished - Aug 19 2015


  • blood flow
  • comorbidity
  • diabetes
  • glaucoma

ASJC Scopus subject areas

  • Ophthalmology

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