Vascular risk factors and cognitive decline in a population sample

Mary Ganguli, Bo Fu, Beth E. Snitz, Frederick Unverzagt, David A. Loewenstein, Tiffany F. Hughes, Chung Chou H Chang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We examined several vascular factors in relation to the rates of decline in 5 cognitive domains in a population-based cohort. In an age-stratified random sample (N=1982) aged 65+ years, we assessed at baseline the cognitive domains of attention, executive function, memory, language, and visuospatial function, and also vascular, inflammatory, and metabolic indices. Random effects models generated slopes of cognitive decline over the next 4 years; linear models identified vascular factors associated with these slopes, adjusting for demographics, baseline cognition, and potential interactions. Several vascular risk factors (history of stroke, diabetes, central obesity, C-reactive protein), although associated with lower baseline cognitive performance, did not predict rate of subsequent decline. APOE*4 genotype was associated with accelerated decline in language, memory, and executive functions. Homocysteine elevation was associated with faster decline in executive function. Hypertension (history or systolic blood pressure >140 mm Hg) was associated with slower decline in memory. Baseline alcohol consumption was associated with slower decline in attention, language, and memory. Different indices of vascular risk are associated with low performance and with rates of decline in different cognitive domains. Cardiovascular mechanisms explain at least some of the variance in cognitive decline. Selective survival may also play a role.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalAlzheimer Disease and Associated Disorders
Volume28
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Executive Function
Language
Population
Blood Vessels
Blood Pressure
Abdominal Obesity
Homocysteine
Alcohol Drinking
C-Reactive Protein
Cognition
Linear Models
History
Stroke
Genotype
Demography
Hypertension
Cognitive Dysfunction
vascular factor

Keywords

  • aging
  • cognitive impairment
  • community study
  • epidemiology
  • longitudinal study
  • prospective study

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Gerontology
  • Clinical Psychology

Cite this

Ganguli, M., Fu, B., Snitz, B. E., Unverzagt, F., Loewenstein, D. A., Hughes, T. F., & Chang, C. C. H. (2014). Vascular risk factors and cognitive decline in a population sample. Alzheimer Disease and Associated Disorders, 28(1), 9-15. https://doi.org/10.1097/WAD.0000000000000004

Vascular risk factors and cognitive decline in a population sample. / Ganguli, Mary; Fu, Bo; Snitz, Beth E.; Unverzagt, Frederick; Loewenstein, David A.; Hughes, Tiffany F.; Chang, Chung Chou H.

In: Alzheimer Disease and Associated Disorders, Vol. 28, No. 1, 01.2014, p. 9-15.

Research output: Contribution to journalArticle

Ganguli, Mary ; Fu, Bo ; Snitz, Beth E. ; Unverzagt, Frederick ; Loewenstein, David A. ; Hughes, Tiffany F. ; Chang, Chung Chou H. / Vascular risk factors and cognitive decline in a population sample. In: Alzheimer Disease and Associated Disorders. 2014 ; Vol. 28, No. 1. pp. 9-15.
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