Vascular smooth muscle progenitor cells: Building and repairing blood vessels

Mark W. Majesky, Xiu Rong Dong, Jenna N. Regan, Virginia J. Hoglund

Research output: Contribution to journalReview article

109 Scopus citations

Abstract

Molecular pathways that control the specification, migration, and number of available smooth muscle progenitor cells play key roles in determining blood vessel size and structure, capacity for tissue repair, and progression of age-related disorders. Defects in these pathways produce malformations of developing blood vessels, depletion of smooth muscle progenitor cell pools for vessel wall maintenance and repair, and aberrant activation of alternative differentiation pathways in vascular disease. A better understanding of the molecular mechanisms that uniquely specify and maintain vascular smooth muscle cell precursors is essential if we are to use advances in stem and progenitor cell biology and somatic cell reprogramming for applications directed to the vessel wall.

Original languageEnglish (US)
Pages (from-to)365-377
Number of pages13
JournalCirculation research
Volume108
Issue number3
DOIs
StatePublished - Feb 4 2011
Externally publishedYes

Keywords

  • adventitia
  • differentiation
  • embryo
  • specification
  • stem cell

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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