Vascularity of meningiomas

Shaheryar F. Ansari, Kushal J. Shah, Wael Hassaneen, Aaron A. Cohen-Gadol

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Information on the vascular supply to meningiomas is critical to the neurosurgeon. Most meningiomas are supplied by the external carotid artery, though many get pial contribution as well. Angiogenesis is critical for these neoplasms to grow. Vascular endothelial growth factor (VEGF) has been a popular target of research to decrease angiogenesis. Peritumoral brain edema (PTBE) is occasionally seen in meningiomas, which makes surgical resection more challenging. The exact cause of PTBE remains unclear, but a number of factors have been postulated to contribute. Assessment of the vascularity of meningiomas is best carried out with angiography, but noninvasive techniques are improving, diminishing the need for more invasive imaging. Embolization of tumors can be performed to minimize perioperative blood loss and potentially lower surgical morbidity. However, it has not been shown to improve outcomes, and procedural risks exist. Higher grade tumors commonly have higher vascularity. Higher vascular meningiomas are more likely to recur and have higher levels of VEGF. The vascularity of meningiomas remains a topic of interest and is the focus of many research projects.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Pages153-165
Number of pages13
DOIs
StatePublished - 2020

Publication series

NameHandbook of Clinical Neurology
Volume169
ISSN (Print)0072-9752
ISSN (Electronic)2212-4152

Keywords

  • Angiogenesis
  • Embolization
  • Noninvasive vascular imaging
  • Peritumoral brain edema
  • Vascular endothelial growth factor
  • Vascular supply

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Ansari, S. F., Shah, K. J., Hassaneen, W., & Cohen-Gadol, A. A. (2020). Vascularity of meningiomas. In Handbook of Clinical Neurology (pp. 153-165). (Handbook of Clinical Neurology; Vol. 169). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-804280-9.00010-X