Vasoconstrictive effects of native tachykinins in the rainbow trout, Oncorhynchus mykiss

J. Kågström, S. Holmgren, Kenneth Olson, J. M. Conlon, J. Jensen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The role of trout substance P (tSP) and neurokinin A (tNKA) in cardiovascular regulation was investigated in the rainbow trout, Oncorhynchus mykiss, in vivo and in vitro. In vivo, the coeliac arterial and ventral aortic relative blood flows were measured with Doppler flow probes, and blood pressure was measured via a cannula inserted into the dorsal aorta. tSP (0.1 and 1 nmol kg-1) and tNKA (1 nmol kg-1) increased both systemic and coeliac vascular resistances, leading to hypertension and bradycardia. In addition, cardiac output was decreased. The mammalian NKI1 tachykinin receptor antagonist CP-96,345 did not affect the responses to tSP or tNKA. In vitro perfusions of the dorsal aortic and coeliacomesenteric vascular beds were performed using peristaltic pumps. The dorsal aortic vascular resistance was dose-dependently increased following infusion of the two peptides (pD2 values 7.6 ± 0.1 and 7.3 ± 0.1 for tSP and tNKA, respectively). Tetrodotoxin did not affect the tSP-induced hypertension. Increases in coeliac vascular resistance caused by tSP was correlated with stomach contractions when measurement of intragastric pressure was made using an inserted balloon. In conclusion, native SP and NKA are potent vasoconstrictors of rainbow trout vasculature, a property quite unusual to tachykinins compared with the vasodilation normally seen in mammals.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalPeptides
Volume17
Issue number1
DOIs
StatePublished - 1996

Fingerprint

Tachykinins
Trout
Oncorhynchus mykiss
Substance P
Neurokinin A
Vascular Resistance
Abdomen
Tachykinin Receptors
Hypertension
Mammals
Balloons
Blood pressure
Tetrodotoxin
Vasoconstrictor Agents
Bradycardia
Vasodilation
Cardiac Output
Blood Vessels
Aorta
Stomach

Keywords

  • Circulation
  • CP-96345
  • Gut
  • Tachykinin receptors
  • Teleost fish
  • Vasoconstriction

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Vasoconstrictive effects of native tachykinins in the rainbow trout, Oncorhynchus mykiss. / Kågström, J.; Holmgren, S.; Olson, Kenneth; Conlon, J. M.; Jensen, J.

In: Peptides, Vol. 17, No. 1, 1996, p. 39-45.

Research output: Contribution to journalArticle

Kågström, J. ; Holmgren, S. ; Olson, Kenneth ; Conlon, J. M. ; Jensen, J. / Vasoconstrictive effects of native tachykinins in the rainbow trout, Oncorhynchus mykiss. In: Peptides. 1996 ; Vol. 17, No. 1. pp. 39-45.
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