Vasoproliferative retinopathies: Clinical, morphogenetic and modulatory aspects

M. E. Boulton, D. McLeod, A. Garner

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In 1948, the year of inception of the Institute of Ophthalmology, Isaac Michaelson presented his now classic paper on retinal neovascularisation to the Ophthalmological Society of the United Kingdom. In it he postulated the existence and role of a biochemical factor of extravascular retinal origin which promotes the growth of capillary blood vessels in both the fetal development of the retinal circulation and preretinally in such pathological conditions as Eales' Disease, proliferative diabetic retinopathy (PDR) and after retinal vein occlusion (RVO), Subsequent events have served to support Michaelson's basic hypothesis, although it was not until the early 1980s that the existence of an angiogenic factor in the retina was convincingly demonstrated and still its precise nature and origin is unknown. This review will focus particularly on advances in knowledge of neovascular morphogenesis, the role of angiogenic factors occurring in the retina, the retinal pigment epithelium (RPE) and the vitreous, and will consider the clinical implications of Michaelson's ideas. This will reflect improved laboratory and clinical investigational methods and the opportunities to influence vasoproliferative retinopathies (VPRs) clinically by retinal photocoagulation and vitrectomy.

Original languageEnglish (US)
JournalEye (Basingstoke)
Volume2
Issue numberSUPPL. 2
StatePublished - 1988
Externally publishedYes

Fingerprint

Angiogenesis Inducing Agents
Retina
Retinal Neovascularization
Retinal Vein Occlusion
Retinal Pigment Epithelium
Light Coagulation
Vitrectomy
Diabetic Retinopathy
Ophthalmology
Fetal Development
Morphogenesis
Blood Vessels
Growth
United Kingdom
Eales disease

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Boulton, M. E., McLeod, D., & Garner, A. (1988). Vasoproliferative retinopathies: Clinical, morphogenetic and modulatory aspects. Eye (Basingstoke), 2(SUPPL. 2).

Vasoproliferative retinopathies : Clinical, morphogenetic and modulatory aspects. / Boulton, M. E.; McLeod, D.; Garner, A.

In: Eye (Basingstoke), Vol. 2, No. SUPPL. 2, 1988.

Research output: Contribution to journalArticle

Boulton, ME, McLeod, D & Garner, A 1988, 'Vasoproliferative retinopathies: Clinical, morphogenetic and modulatory aspects', Eye (Basingstoke), vol. 2, no. SUPPL. 2.
Boulton, M. E. ; McLeod, D. ; Garner, A. / Vasoproliferative retinopathies : Clinical, morphogenetic and modulatory aspects. In: Eye (Basingstoke). 1988 ; Vol. 2, No. SUPPL. 2.
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