Venous Hemodynamics in a Chronic Venous Valvular Insufficiency Model

Stephen G. Lalka, Joseph L. Unthank, Michael C. Dalsing, Dolores F. Cikrit, Alan P. Sawchuk

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To develop a large-animal model of chronic venous valve incompetence, 13 greyhound dogs underwent unilateral hindlimb venous valve lysis with a valve cutter apparatus pulled retrograde through the iliac, femoral, and lateral saphenous veins. Bilateral venous pressures in the lateral saphenous vein were recorded before valve lysis, immediately after valve lysis, and at intervals from 1 to 14 weeks after valve lysis, with the dogs in the supine position and elevated 80° semierect, as well as after stimulated hindlimb muscle contraction to empty the hindlimb veins. Passive venous filling time with elevation and 90% venous refilling time after muscle contraction were calculated. From immediately after through 14 weeks after valve lysis, a shortened venous filling time and 90% venour refilling time as well as an elevated poststimulation venous pressure were noted. This valve lysis method successfully produced a hemodynamically verified model of venous valvular insufficiency.

Original languageEnglish (US)
Pages (from-to)1579-1583
Number of pages5
JournalArchives of Surgery
Volume125
Issue number12
DOIs
StatePublished - Dec 1990

ASJC Scopus subject areas

  • Surgery

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