Venous Thromboembolism in Necrotizing Pancreatitis

an Underappreciated Risk

Alexandra M. Roch, Thomas K. Maatman, Rose A. Carr, Cameron L. Colgate, Eugene P. Ceppa, Michael House, James Lopes, Attila Nakeeb, C. Schmidt, Nicholas Zyromski

Research output: Contribution to journalArticle

Abstract

Background: Necrotizing pancreatitis (NP) is a severe systemic inflammatory process. We have observed a high incidence of venous thromboembolism (VTE) in NP patients. However, remarkably few data exist to document the true incidence of VTE—including splanchnic vein thrombosis (SVT), extremity deep venous thrombosis (eDVT), and pulmonary embolism (PE)—in NP. Therefore, we sought to determine the incidence and risk factors for VTE in NP patients. Methods: Retrospective review of all NP patients treated at a single academic center between 2005 and 2015. VTE diagnosis was confirmed by ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and/or ventilation/perfusion (V/Q) scan. Descriptive statistics and univariate analysis were applied where appropriate; p value < 0.05 was considered statistically significant. Results: Five hundred and forty-five NP patients (median age 53 years; 65% males) were reviewed. VTE was diagnosed in 312 patients (57%). SVT was found in 50%, eDVT in 16%, and PE in 6%. VTE in multiple sites was found in 22% of patients. VTE was diagnosed a median of 37 days following pancreatitis diagnosis. Seventy-nine percent of patients required at least one surgical procedure over the course of their NP. Patients requiring surgery had a DVT incidence of 58%; however, VTE was diagnosed preoperatively in 63%. Male gender, history of previous DVT, infected necrosis, development of organ failure, and development of respiratory failure were identified as risk factors for VTE (p = 0.001–0.04) by univariate analysis. Conclusions: Venous thromboembolism is extremely common in necrotizing pancreatitis. Regular ultrasound screening may be considered to facilitate early diagnosis in this extremely high-risk population.

Original languageEnglish (US)
JournalJournal of Gastrointestinal Surgery
DOIs
StatePublished - Jan 1 2019

Fingerprint

Venous Thromboembolism
Pancreatitis
Viscera
Incidence
Pulmonary Embolism
Venous Thrombosis
Veins
Extremities
Respiratory Insufficiency
Ventilation
Early Diagnosis
Thrombosis
Necrosis
Perfusion
Tomography
Magnetic Resonance Imaging

Keywords

  • Acute necrotizing pancreatitis
  • Deep venous thrombosis
  • Venous thromboembolism
  • Venous thrombosis

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Venous Thromboembolism in Necrotizing Pancreatitis : an Underappreciated Risk. / Roch, Alexandra M.; Maatman, Thomas K.; Carr, Rose A.; Colgate, Cameron L.; Ceppa, Eugene P.; House, Michael; Lopes, James; Nakeeb, Attila; Schmidt, C.; Zyromski, Nicholas.

In: Journal of Gastrointestinal Surgery, 01.01.2019.

Research output: Contribution to journalArticle

Roch, Alexandra M. ; Maatman, Thomas K. ; Carr, Rose A. ; Colgate, Cameron L. ; Ceppa, Eugene P. ; House, Michael ; Lopes, James ; Nakeeb, Attila ; Schmidt, C. ; Zyromski, Nicholas. / Venous Thromboembolism in Necrotizing Pancreatitis : an Underappreciated Risk. In: Journal of Gastrointestinal Surgery. 2019.
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abstract = "Background: Necrotizing pancreatitis (NP) is a severe systemic inflammatory process. We have observed a high incidence of venous thromboembolism (VTE) in NP patients. However, remarkably few data exist to document the true incidence of VTE—including splanchnic vein thrombosis (SVT), extremity deep venous thrombosis (eDVT), and pulmonary embolism (PE)—in NP. Therefore, we sought to determine the incidence and risk factors for VTE in NP patients. Methods: Retrospective review of all NP patients treated at a single academic center between 2005 and 2015. VTE diagnosis was confirmed by ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and/or ventilation/perfusion (V/Q) scan. Descriptive statistics and univariate analysis were applied where appropriate; p value < 0.05 was considered statistically significant. Results: Five hundred and forty-five NP patients (median age 53 years; 65{\%} males) were reviewed. VTE was diagnosed in 312 patients (57{\%}). SVT was found in 50{\%}, eDVT in 16{\%}, and PE in 6{\%}. VTE in multiple sites was found in 22{\%} of patients. VTE was diagnosed a median of 37 days following pancreatitis diagnosis. Seventy-nine percent of patients required at least one surgical procedure over the course of their NP. Patients requiring surgery had a DVT incidence of 58{\%}; however, VTE was diagnosed preoperatively in 63{\%}. Male gender, history of previous DVT, infected necrosis, development of organ failure, and development of respiratory failure were identified as risk factors for VTE (p = 0.001–0.04) by univariate analysis. Conclusions: Venous thromboembolism is extremely common in necrotizing pancreatitis. Regular ultrasound screening may be considered to facilitate early diagnosis in this extremely high-risk population.",
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T2 - an Underappreciated Risk

AU - Roch, Alexandra M.

AU - Maatman, Thomas K.

AU - Carr, Rose A.

AU - Colgate, Cameron L.

AU - Ceppa, Eugene P.

AU - House, Michael

AU - Lopes, James

AU - Nakeeb, Attila

AU - Schmidt, C.

AU - Zyromski, Nicholas

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AB - Background: Necrotizing pancreatitis (NP) is a severe systemic inflammatory process. We have observed a high incidence of venous thromboembolism (VTE) in NP patients. However, remarkably few data exist to document the true incidence of VTE—including splanchnic vein thrombosis (SVT), extremity deep venous thrombosis (eDVT), and pulmonary embolism (PE)—in NP. Therefore, we sought to determine the incidence and risk factors for VTE in NP patients. Methods: Retrospective review of all NP patients treated at a single academic center between 2005 and 2015. VTE diagnosis was confirmed by ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and/or ventilation/perfusion (V/Q) scan. Descriptive statistics and univariate analysis were applied where appropriate; p value < 0.05 was considered statistically significant. Results: Five hundred and forty-five NP patients (median age 53 years; 65% males) were reviewed. VTE was diagnosed in 312 patients (57%). SVT was found in 50%, eDVT in 16%, and PE in 6%. VTE in multiple sites was found in 22% of patients. VTE was diagnosed a median of 37 days following pancreatitis diagnosis. Seventy-nine percent of patients required at least one surgical procedure over the course of their NP. Patients requiring surgery had a DVT incidence of 58%; however, VTE was diagnosed preoperatively in 63%. Male gender, history of previous DVT, infected necrosis, development of organ failure, and development of respiratory failure were identified as risk factors for VTE (p = 0.001–0.04) by univariate analysis. Conclusions: Venous thromboembolism is extremely common in necrotizing pancreatitis. Regular ultrasound screening may be considered to facilitate early diagnosis in this extremely high-risk population.

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KW - Deep venous thrombosis

KW - Venous thromboembolism

KW - Venous thrombosis

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