Ventilation and oxygenation changes during sleep in cystic fibrosis

R. S. Tepper, J. B. Skatrud, J. A. Dempsey

Research output: Contribution to journalArticle

60 Scopus citations


Oxygen desaturation during sleep in patients with cystic fibrosis has been attributed to changes in the end-expiratory volume during rapid eye movement (REM) sleep, leading to worsening of the ventilation-perfusion distribution. The purpose of this study was to describe the changes in ventilation during sleep that may contribute to the oxygen desaturation. Six adolescent males with moderate to severe cystic fibrosis were studied. It was concluded that hypoventilation during REM may contribute to oxygen desaturation in patients with cystic fibrosis.

Original languageEnglish (US)
Pages (from-to)388-393
Number of pages6
Issue number4
StatePublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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