Ventilation homogeneity improves with growth early in life

Valentina C. Chakr, Conrado J. Llapur, Edgar E. Sarria, Rita Mattiello, Jeffrey Kisling, Christina Tiller, Risa Kimmel, Brenda Poindexter, Robert Tepper

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Some studies have suggested that lung clearance index (LCI) is age-independent among healthy subjects early in life, which implies that ventilation distribution does not vary with growth. However, other studies of older children and adolescents suggest that ventilation becomes more homogenous with somatic growth. We describe a new technique to obtain multiple breath washout (MBWO) in sedated infants and toddlers using slow augmented inflation breaths that yields an assessment of LCI and the slope of phase III, which is another index of ventilation inhomogeneity. We evaluated whether ventilation becomes more homogenous with increasing age early in life, and whether infants with chronic lung disease of infancy (CLDI) have increased ventilation inhomogeneity relative to full-term controls (FT). FT (N = 28) and CLDI (N = 22) subjects between 3 and 28 months corrected-age were evaluated. LCI decreased with increasing age; however, there was no significant difference between the two groups (9.3 vs. 9.5; P = 0.56). Phase III slopes adjusted for expired volume (S ND) increased with increasing breath number during the washout and decreased with increasing age. There was no significant difference in S ND between full-term and CLDI subjects (211 vs. 218; P = 0.77). Our findings indicate that ventilation becomes more homogenous with lung growth and maturation early in life; however, there is no evidence that ventilation inhomogeneity is a significant component of the pulmonary pathophysiology of CLDI. Pediatr Pulmonol. 2012; 47:373-380.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalPediatric Pulmonology
Volume47
Issue number4
DOIs
StatePublished - Apr 2012

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Ventilation
Lung Diseases
Growth
Chronic Disease
Lung
Economic Inflation
Healthy Volunteers

Keywords

  • bronchopulmonary dysplasia
  • chronic lung disease of infancy
  • infant
  • lung clearance index
  • lung function tests
  • phase III slope
  • premature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Chakr, V. C., Llapur, C. J., Sarria, E. E., Mattiello, R., Kisling, J., Tiller, C., ... Tepper, R. (2012). Ventilation homogeneity improves with growth early in life. Pediatric Pulmonology, 47(4), 373-380. https://doi.org/10.1002/ppul.21553

Ventilation homogeneity improves with growth early in life. / Chakr, Valentina C.; Llapur, Conrado J.; Sarria, Edgar E.; Mattiello, Rita; Kisling, Jeffrey; Tiller, Christina; Kimmel, Risa; Poindexter, Brenda; Tepper, Robert.

In: Pediatric Pulmonology, Vol. 47, No. 4, 04.2012, p. 373-380.

Research output: Contribution to journalArticle

Chakr, VC, Llapur, CJ, Sarria, EE, Mattiello, R, Kisling, J, Tiller, C, Kimmel, R, Poindexter, B & Tepper, R 2012, 'Ventilation homogeneity improves with growth early in life', Pediatric Pulmonology, vol. 47, no. 4, pp. 373-380. https://doi.org/10.1002/ppul.21553
Chakr VC, Llapur CJ, Sarria EE, Mattiello R, Kisling J, Tiller C et al. Ventilation homogeneity improves with growth early in life. Pediatric Pulmonology. 2012 Apr;47(4):373-380. https://doi.org/10.1002/ppul.21553
Chakr, Valentina C. ; Llapur, Conrado J. ; Sarria, Edgar E. ; Mattiello, Rita ; Kisling, Jeffrey ; Tiller, Christina ; Kimmel, Risa ; Poindexter, Brenda ; Tepper, Robert. / Ventilation homogeneity improves with growth early in life. In: Pediatric Pulmonology. 2012 ; Vol. 47, No. 4. pp. 373-380.
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