Ventricular arrhythmia in structurally remodeled hearts and potential role of myocardial fibrosis

Thomas H. Everett, Jeffrey E. Olgin

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Heart failure and ischemic heart disease introduce an environment in which structural and electrical remodeling of the ventricular tissue occurs. These changes can then predispose to ventricular arrhythmias. In heart failure alone, these changes include both electrical remodeling of prolonged action potential duration (APD) and increased dispersion of refractoriness and structural remodeling that is associated with increased cell size, reduced connexin43 distribution, ion channel downregulation, and stimulation of TGF-β which can then lead to increased microfibrosis and interstitial fibrosis. Increased myocardial fibrosis can then lead to changes in cardiac fiber orientation which can then alter electrical conduction. Collectively, these changes alter the ventricular substrate which can then alter the mechanisms and characteristics of any resulting ventricular arrythmias. In this chapter we will discuss these structural changes that occur, how it effects conduction, which can ultimately lead to arrhythmias.

Original languageEnglish (US)
Title of host publicationVentricular Arrhythmia
Subtitle of host publicationFrom Principles to Patients
PublisherNova Science Publishers, Inc.
Pages37-50
Number of pages14
ISBN (Print)9781620815403
StatePublished - Feb 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Everett, T. H., & Olgin, J. E. (2013). Ventricular arrhythmia in structurally remodeled hearts and potential role of myocardial fibrosis. In Ventricular Arrhythmia: From Principles to Patients (pp. 37-50). Nova Science Publishers, Inc..