Ventricular arrhythmia in structurally remodeled hearts and potential role of myocardial fibrosis

Thomas Everett, Jeffrey E. Olgin

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Heart failure and ischemic heart disease introduce an environment in which structural and electrical remodeling of the ventricular tissue occurs. These changes can then predispose to ventricular arrhythmias. In heart failure alone, these changes include both electrical remodeling of prolonged action potential duration (APD) and increased dispersion of refractoriness and structural remodeling that is associated with increased cell size, reduced connexin43 distribution, ion channel downregulation, and stimulation of TGF-β which can then lead to increased microfibrosis and interstitial fibrosis. Increased myocardial fibrosis can then lead to changes in cardiac fiber orientation which can then alter electrical conduction. Collectively, these changes alter the ventricular substrate which can then alter the mechanisms and characteristics of any resulting ventricular arrythmias. In this chapter we will discuss these structural changes that occur, how it effects conduction, which can ultimately lead to arrhythmias.

Original languageEnglish (US)
Title of host publicationVentricular Arrhythmia: From Principles to Patients
PublisherNova Science Publishers, Inc.
Pages37-50
Number of pages14
ISBN (Print)9781620815403
StatePublished - Feb 2013
Externally publishedYes

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Atrial Remodeling
Cardiac Arrhythmias
Fibrosis
Heart Failure
Connexin 43
Ion Channels
Cell Size
Action Potentials
Myocardial Ischemia
Down-Regulation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Everett, T., & Olgin, J. E. (2013). Ventricular arrhythmia in structurally remodeled hearts and potential role of myocardial fibrosis. In Ventricular Arrhythmia: From Principles to Patients (pp. 37-50). Nova Science Publishers, Inc..

Ventricular arrhythmia in structurally remodeled hearts and potential role of myocardial fibrosis. / Everett, Thomas; Olgin, Jeffrey E.

Ventricular Arrhythmia: From Principles to Patients. Nova Science Publishers, Inc., 2013. p. 37-50.

Research output: Chapter in Book/Report/Conference proceedingChapter

Everett, T & Olgin, JE 2013, Ventricular arrhythmia in structurally remodeled hearts and potential role of myocardial fibrosis. in Ventricular Arrhythmia: From Principles to Patients. Nova Science Publishers, Inc., pp. 37-50.
Everett T, Olgin JE. Ventricular arrhythmia in structurally remodeled hearts and potential role of myocardial fibrosis. In Ventricular Arrhythmia: From Principles to Patients. Nova Science Publishers, Inc. 2013. p. 37-50
Everett, Thomas ; Olgin, Jeffrey E. / Ventricular arrhythmia in structurally remodeled hearts and potential role of myocardial fibrosis. Ventricular Arrhythmia: From Principles to Patients. Nova Science Publishers, Inc., 2013. pp. 37-50
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