Ventricular Fibrillation during Antiarrhythmic Drug Therapy

Robert K. Rude, Elisabeth Ryzen, Eric N. Prystowsky, Douglas P. Zipes

Research output: Contribution to journalLetter

1 Scopus citations


To the Editor: Minardo et al.1 and Horowitz2 (Aug. 4 issue) concluded that drug-associated ventricular fibrillation does occur and may be accompanied by concomitant therapy with digitalis and diuretics as well as by hypokalemia. Magnesium is the forgotten cation. Ventricular premature complexes, ventricular tachycardia, and ventricular fibrillation are known complications of magnesium deficiency.3 4 5 Magnesium depletion also renders the heart more susceptible to the arrhythmogenic effects of cardiac glycosides,6 7 8 and such patients may be very sensitive to magnesium therapy.9 Intracellular potassium depletion and hypokalemia are well-recognized complications of magnesium deficiency10,11 and may be due to the inability of the kidney to…

Original languageEnglish (US)
Pages (from-to)537-538
Number of pages2
JournalNew England Journal of Medicine
Issue number8
StatePublished - Feb 23 1989

ASJC Scopus subject areas

  • Medicine(all)

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