Ventricular fibrillation

How do we stop the waves from breaking?

James N. Weiss, Peng-Sheng Chen, Zhilin Qu, Hrayr S. Karagueuzian, Alan Garfinkel

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably alter electrical restitution properties have promise as a new paradigm for preventing fibrillation.

Original languageEnglish (US)
Pages (from-to)1103-1107
Number of pages5
JournalCirculation Research
Volume87
Issue number12
StatePublished - Dec 8 2000
Externally publishedYes

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Ventricular Fibrillation
Therapeutics

Keywords

  • Antiarrhythmic drugs
  • Arrhythmias
  • Cardiac action potential
  • Electrical restitution
  • Fibrillation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Weiss, J. N., Chen, P-S., Qu, Z., Karagueuzian, H. S., & Garfinkel, A. (2000). Ventricular fibrillation: How do we stop the waves from breaking? Circulation Research, 87(12), 1103-1107.

Ventricular fibrillation : How do we stop the waves from breaking? / Weiss, James N.; Chen, Peng-Sheng; Qu, Zhilin; Karagueuzian, Hrayr S.; Garfinkel, Alan.

In: Circulation Research, Vol. 87, No. 12, 08.12.2000, p. 1103-1107.

Research output: Contribution to journalArticle

Weiss, JN, Chen, P-S, Qu, Z, Karagueuzian, HS & Garfinkel, A 2000, 'Ventricular fibrillation: How do we stop the waves from breaking?', Circulation Research, vol. 87, no. 12, pp. 1103-1107.
Weiss JN, Chen P-S, Qu Z, Karagueuzian HS, Garfinkel A. Ventricular fibrillation: How do we stop the waves from breaking? Circulation Research. 2000 Dec 8;87(12):1103-1107.
Weiss, James N. ; Chen, Peng-Sheng ; Qu, Zhilin ; Karagueuzian, Hrayr S. ; Garfinkel, Alan. / Ventricular fibrillation : How do we stop the waves from breaking?. In: Circulation Research. 2000 ; Vol. 87, No. 12. pp. 1103-1107.
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