Ventricular fibrillation: How do we stop the waves from breaking?

James N. Weiss, Peng Sheng Chen, Zhilin Qu, Hrayr S. Karagueuzian, Alan Garfinkel

Research output: Contribution to journalReview article

178 Scopus citations

Abstract

Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably alter electrical restitution properties have promise as a new paradigm for preventing fibrillation.

Original languageEnglish (US)
Pages (from-to)1103-1107
Number of pages5
JournalCirculation research
Volume87
Issue number12
DOIs
StatePublished - Dec 8 2000
Externally publishedYes

Keywords

  • Antiarrhythmic drugs
  • Arrhythmias
  • Cardiac action potential
  • Electrical restitution
  • Fibrillation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Weiss, J. N., Chen, P. S., Qu, Z., Karagueuzian, H. S., & Garfinkel, A. (2000). Ventricular fibrillation: How do we stop the waves from breaking? Circulation research, 87(12), 1103-1107. https://doi.org/10.1161/01.RES.87.12.1103