Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably alter electrical restitution properties have promise as a new paradigm for preventing fibrillation.
- Antiarrhythmic drugs
- Cardiac action potential
- Electrical restitution
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine