Ventricular fibrillation: New insights into mechanisms

James N. Weiss, Peng-Sheng Chen, Tsu Juey Wu, Carin Siegerman, Alan Garfinkel

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Device therapy with implantable cardioverter-defibrillators is currently the only proven effective therapy against sudden cardiac death due to ventricular fibrillation. However, the expanded clinical indications for device therapy come at a staggering cost to an already overburdened health care system. Given these statistics, it is both highly desirable and economically imperative to develop alternative therapies. New insights into the mechanisms of ventricular fibrillation, particularly the role of dynamic factors causing wave instability, are providing a promising avenue for developing novel therapies to prevent sudden cardiac death.

Original languageEnglish (US)
Pages (from-to)122-132
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume1015
DOIs
StatePublished - 2004
Externally publishedYes

Fingerprint

Implantable cardioverter defibrillators
Ventricular Fibrillation
Health care
Statistics
Sudden Cardiac Death
Costs
Equipment and Supplies
Implantable Defibrillators
Therapeutics
Complementary Therapies
Delivery of Health Care
Costs and Cost Analysis
Therapy

Keywords

  • Action potential
  • Arrhythmias
  • Restitution
  • Sudden cardiac death

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ventricular fibrillation : New insights into mechanisms. / Weiss, James N.; Chen, Peng-Sheng; Wu, Tsu Juey; Siegerman, Carin; Garfinkel, Alan.

In: Annals of the New York Academy of Sciences, Vol. 1015, 2004, p. 122-132.

Research output: Contribution to journalArticle

Weiss, James N. ; Chen, Peng-Sheng ; Wu, Tsu Juey ; Siegerman, Carin ; Garfinkel, Alan. / Ventricular fibrillation : New insights into mechanisms. In: Annals of the New York Academy of Sciences. 2004 ; Vol. 1015. pp. 122-132.
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