Abstract
Device therapy with implantable cardioverter-defibrillators is currently the only proven effective therapy against sudden cardiac death due to ventricular fibrillation. However, the expanded clinical indications for device therapy come at a staggering cost to an already overburdened health care system. Given these statistics, it is both highly desirable and economically imperative to develop alternative therapies. New insights into the mechanisms of ventricular fibrillation, particularly the role of dynamic factors causing wave instability, are providing a promising avenue for developing novel therapies to prevent sudden cardiac death.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 122-132 |
| Number of pages | 11 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1015 |
| DOIs | |
| State | Published - 2004 |
| Externally published | Yes |
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Keywords
- Action potential
- Arrhythmias
- Restitution
- Sudden cardiac death
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Ventricular fibrillation : New insights into mechanisms. / Weiss, James N.; Chen, Peng-Sheng; Wu, Tsu Juey; Siegerman, Carin; Garfinkel, Alan.
In: Annals of the New York Academy of Sciences, Vol. 1015, 2004, p. 122-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ventricular fibrillation
T2 - New insights into mechanisms
AU - Weiss, James N.
AU - Chen, Peng-Sheng
AU - Wu, Tsu Juey
AU - Siegerman, Carin
AU - Garfinkel, Alan
PY - 2004
Y1 - 2004
N2 - Device therapy with implantable cardioverter-defibrillators is currently the only proven effective therapy against sudden cardiac death due to ventricular fibrillation. However, the expanded clinical indications for device therapy come at a staggering cost to an already overburdened health care system. Given these statistics, it is both highly desirable and economically imperative to develop alternative therapies. New insights into the mechanisms of ventricular fibrillation, particularly the role of dynamic factors causing wave instability, are providing a promising avenue for developing novel therapies to prevent sudden cardiac death.
AB - Device therapy with implantable cardioverter-defibrillators is currently the only proven effective therapy against sudden cardiac death due to ventricular fibrillation. However, the expanded clinical indications for device therapy come at a staggering cost to an already overburdened health care system. Given these statistics, it is both highly desirable and economically imperative to develop alternative therapies. New insights into the mechanisms of ventricular fibrillation, particularly the role of dynamic factors causing wave instability, are providing a promising avenue for developing novel therapies to prevent sudden cardiac death.
KW - Action potential
KW - Arrhythmias
KW - Restitution
KW - Sudden cardiac death
UR - http://www.scopus.com/inward/record.url?scp=3042840735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042840735&partnerID=8YFLogxK
U2 - 10.1196/annals.1302.010
DO - 10.1196/annals.1302.010
M3 - Article
VL - 1015
SP - 122
EP - 132
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -