Ventricular fibrillation: New insights into mechanisms

James N. Weiss, Peng Sheng Chen, Tsu Juey Wu, Carin Siegerman, Alan Garfinkel

Research output: Contribution to journalArticle

16 Scopus citations


Device therapy with implantable cardioverter-defibrillators is currently the only proven effective therapy against sudden cardiac death due to ventricular fibrillation. However, the expanded clinical indications for device therapy come at a staggering cost to an already overburdened health care system. Given these statistics, it is both highly desirable and economically imperative to develop alternative therapies. New insights into the mechanisms of ventricular fibrillation, particularly the role of dynamic factors causing wave instability, are providing a promising avenue for developing novel therapies to prevent sudden cardiac death.

Original languageEnglish (US)
Pages (from-to)122-132
Number of pages11
JournalAnnals of the New York Academy of Sciences
StatePublished - 2004


  • Action potential
  • Arrhythmias
  • Restitution
  • Sudden cardiac death

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Weiss, J. N., Chen, P. S., Wu, T. J., Siegerman, C., & Garfinkel, A. (2004). Ventricular fibrillation: New insights into mechanisms. Annals of the New York Academy of Sciences, 1015, 122-132.