Verapamil prolongs atrial fibrillation by evoking an intense sympathetic neurohumoral effect

Howard S. Friedman, Evans Rodney, Bindeshwari Sinha, Amir Sharafkhaneh, Norrapol Wattanasuwan, Moethu Win, Dayaker Mallipeddi, Anjan Sinha, Akhtar Hussain, Chen Pu Dai

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Verapamil is an effective drug to slow ventricular rate in atrial fibrillation (AF). Clinically, however, IV verapamil enhances AF despite experimental evidence suggesting favorable effects of the drug on AF-induced electrical remodeling of the atria. Methods and Results: To clarify this controversy, IV verapamil's effects were determined in 41 anesthetized dogs, including 6 after beta-blockade. Intravenous verapamil (0.20 mg/kg, bolus, and 0.20 mg/kg/h, infusion) increased the duration of AF (induced by a single extrastimulus), from 19 ± 6 to 130 ± 24 s, P-1, P

Original languageEnglish (US)
Pages (from-to)293-303
Number of pages11
JournalJournal of Investigative Medicine
Volume47
Issue number6
StatePublished - Jul 1999
Externally publishedYes

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Verapamil
Atrial Fibrillation
Atrial Remodeling
Pharmaceutical Preparations
Dogs

Keywords

  • Antiarrhythmia agents
  • Atrial fibrillation
  • Calcium channel antagonist
  • Catecholamines
  • Electrophysiology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Friedman, H. S., Rodney, E., Sinha, B., Sharafkhaneh, A., Wattanasuwan, N., Win, M., ... Dai, C. P. (1999). Verapamil prolongs atrial fibrillation by evoking an intense sympathetic neurohumoral effect. Journal of Investigative Medicine, 47(6), 293-303.

Verapamil prolongs atrial fibrillation by evoking an intense sympathetic neurohumoral effect. / Friedman, Howard S.; Rodney, Evans; Sinha, Bindeshwari; Sharafkhaneh, Amir; Wattanasuwan, Norrapol; Win, Moethu; Mallipeddi, Dayaker; Sinha, Anjan; Hussain, Akhtar; Dai, Chen Pu.

In: Journal of Investigative Medicine, Vol. 47, No. 6, 07.1999, p. 293-303.

Research output: Contribution to journalArticle

Friedman, HS, Rodney, E, Sinha, B, Sharafkhaneh, A, Wattanasuwan, N, Win, M, Mallipeddi, D, Sinha, A, Hussain, A & Dai, CP 1999, 'Verapamil prolongs atrial fibrillation by evoking an intense sympathetic neurohumoral effect', Journal of Investigative Medicine, vol. 47, no. 6, pp. 293-303.
Friedman HS, Rodney E, Sinha B, Sharafkhaneh A, Wattanasuwan N, Win M et al. Verapamil prolongs atrial fibrillation by evoking an intense sympathetic neurohumoral effect. Journal of Investigative Medicine. 1999 Jul;47(6):293-303.
Friedman, Howard S. ; Rodney, Evans ; Sinha, Bindeshwari ; Sharafkhaneh, Amir ; Wattanasuwan, Norrapol ; Win, Moethu ; Mallipeddi, Dayaker ; Sinha, Anjan ; Hussain, Akhtar ; Dai, Chen Pu. / Verapamil prolongs atrial fibrillation by evoking an intense sympathetic neurohumoral effect. In: Journal of Investigative Medicine. 1999 ; Vol. 47, No. 6. pp. 293-303.
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