Vertical lines in distal esophageal mucosa (VLEM): A true endoscopic manifestation of esophagitis in children?

S. K. Gupta, J. F. Fitzgerald, S. K.F. Chong, J. M. Croffie, M. H. Collins

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Background: We observed an endoscopic abnormality in a group of children with histological esophagitis. We termed this finding 'vertical lines in esophageal mucosa' (VLEM). We examined the relationship between the presence of VLEM and significant histologic changes in esophageal mucosal biopsies. Methods: Between January 1, 1992, and August 31, 1994, the senior author (JFF) performed 255 esophageal biopsies. The procedure reports, available endoscopic photographs, and histology reports were reviewed to establish the endoscopic and histologic appearance of the esophageal mucosa. Intraepithelial cells were counted in a blind review of 42 randomly selected biopsies. Results: The esophageal mucosa had a normal appearance on 160 endoscopic studies (Group 1) and VLEM were the only mucosal abnormalities in 41 endoscopies (Group 2). Histology was normal in 92 of 160 biopsies (57.5%) from Group 1, and 1 of 41 bops es (2.4%) from Group 2. Most patients in Group 2 had eosinophilic esophagitis (34 of 41, 83%, specificity 0.85, sensitivity 0.5, p < 0.001) which was of moderate to severe intensity (31 of 34, 91.2%, specificity 0.88, sensitivity 0.73, p < 0.001). Conclusions: Histology usually demonstrated moderate to severe inflammation when VLEM were present. VLEM may be a highly specific endoscopic feature of esophagitis in children.

Original languageEnglish (US)
Pages (from-to)485-489
Number of pages5
JournalGastrointestinal endoscopy
Volume45
Issue number6
DOIs
StatePublished - Jan 1 1997

Fingerprint

Esophagitis
Biopsy
Histology
Eosinophilic Esophagitis
Sensitivity and Specificity
Esophageal Mucosa
Endoscopy
Inflammation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Vertical lines in distal esophageal mucosa (VLEM) : A true endoscopic manifestation of esophagitis in children? / Gupta, S. K.; Fitzgerald, J. F.; Chong, S. K.F.; Croffie, J. M.; Collins, M. H.

In: Gastrointestinal endoscopy, Vol. 45, No. 6, 01.01.1997, p. 485-489.

Research output: Contribution to journalArticle

@article{25a4dfd931b24c7bb219235f11925d38,
title = "Vertical lines in distal esophageal mucosa (VLEM): A true endoscopic manifestation of esophagitis in children?",
abstract = "Background: We observed an endoscopic abnormality in a group of children with histological esophagitis. We termed this finding 'vertical lines in esophageal mucosa' (VLEM). We examined the relationship between the presence of VLEM and significant histologic changes in esophageal mucosal biopsies. Methods: Between January 1, 1992, and August 31, 1994, the senior author (JFF) performed 255 esophageal biopsies. The procedure reports, available endoscopic photographs, and histology reports were reviewed to establish the endoscopic and histologic appearance of the esophageal mucosa. Intraepithelial cells were counted in a blind review of 42 randomly selected biopsies. Results: The esophageal mucosa had a normal appearance on 160 endoscopic studies (Group 1) and VLEM were the only mucosal abnormalities in 41 endoscopies (Group 2). Histology was normal in 92 of 160 biopsies (57.5{\%}) from Group 1, and 1 of 41 bops es (2.4{\%}) from Group 2. Most patients in Group 2 had eosinophilic esophagitis (34 of 41, 83{\%}, specificity 0.85, sensitivity 0.5, p < 0.001) which was of moderate to severe intensity (31 of 34, 91.2{\%}, specificity 0.88, sensitivity 0.73, p < 0.001). Conclusions: Histology usually demonstrated moderate to severe inflammation when VLEM were present. VLEM may be a highly specific endoscopic feature of esophagitis in children.",
author = "Gupta, {S. K.} and Fitzgerald, {J. F.} and Chong, {S. K.F.} and Croffie, {J. M.} and Collins, {M. H.}",
year = "1997",
month = "1",
day = "1",
doi = "10.1016/S0016-5107(97)70178-0",
language = "English (US)",
volume = "45",
pages = "485--489",
journal = "Gastrointestinal Endoscopy",
issn = "0016-5107",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Vertical lines in distal esophageal mucosa (VLEM)

T2 - A true endoscopic manifestation of esophagitis in children?

AU - Gupta, S. K.

AU - Fitzgerald, J. F.

AU - Chong, S. K.F.

AU - Croffie, J. M.

AU - Collins, M. H.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Background: We observed an endoscopic abnormality in a group of children with histological esophagitis. We termed this finding 'vertical lines in esophageal mucosa' (VLEM). We examined the relationship between the presence of VLEM and significant histologic changes in esophageal mucosal biopsies. Methods: Between January 1, 1992, and August 31, 1994, the senior author (JFF) performed 255 esophageal biopsies. The procedure reports, available endoscopic photographs, and histology reports were reviewed to establish the endoscopic and histologic appearance of the esophageal mucosa. Intraepithelial cells were counted in a blind review of 42 randomly selected biopsies. Results: The esophageal mucosa had a normal appearance on 160 endoscopic studies (Group 1) and VLEM were the only mucosal abnormalities in 41 endoscopies (Group 2). Histology was normal in 92 of 160 biopsies (57.5%) from Group 1, and 1 of 41 bops es (2.4%) from Group 2. Most patients in Group 2 had eosinophilic esophagitis (34 of 41, 83%, specificity 0.85, sensitivity 0.5, p < 0.001) which was of moderate to severe intensity (31 of 34, 91.2%, specificity 0.88, sensitivity 0.73, p < 0.001). Conclusions: Histology usually demonstrated moderate to severe inflammation when VLEM were present. VLEM may be a highly specific endoscopic feature of esophagitis in children.

AB - Background: We observed an endoscopic abnormality in a group of children with histological esophagitis. We termed this finding 'vertical lines in esophageal mucosa' (VLEM). We examined the relationship between the presence of VLEM and significant histologic changes in esophageal mucosal biopsies. Methods: Between January 1, 1992, and August 31, 1994, the senior author (JFF) performed 255 esophageal biopsies. The procedure reports, available endoscopic photographs, and histology reports were reviewed to establish the endoscopic and histologic appearance of the esophageal mucosa. Intraepithelial cells were counted in a blind review of 42 randomly selected biopsies. Results: The esophageal mucosa had a normal appearance on 160 endoscopic studies (Group 1) and VLEM were the only mucosal abnormalities in 41 endoscopies (Group 2). Histology was normal in 92 of 160 biopsies (57.5%) from Group 1, and 1 of 41 bops es (2.4%) from Group 2. Most patients in Group 2 had eosinophilic esophagitis (34 of 41, 83%, specificity 0.85, sensitivity 0.5, p < 0.001) which was of moderate to severe intensity (31 of 34, 91.2%, specificity 0.88, sensitivity 0.73, p < 0.001). Conclusions: Histology usually demonstrated moderate to severe inflammation when VLEM were present. VLEM may be a highly specific endoscopic feature of esophagitis in children.

UR - http://www.scopus.com/inward/record.url?scp=0030823405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030823405&partnerID=8YFLogxK

U2 - 10.1016/S0016-5107(97)70178-0

DO - 10.1016/S0016-5107(97)70178-0

M3 - Article

C2 - 9199905

AN - SCOPUS:0030823405

VL - 45

SP - 485

EP - 489

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

SN - 0016-5107

IS - 6

ER -