Vesicourethral anastomosis biopsy after radical prostatectomy

predictive value of prostate-specific antigen and pathologic stage.

B. Shekarriz, J. Upadhyay, D. P. Wood, J. Hinman, J. Raasch, G. D. Cummings, David Grignon, P. J. Littrup

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

OBJECTIVES: To assess the role of clinical parameters and pathologic stage in predicting a positive vesicourethral anastomosis (VUA) biopsy in patients with a rising prostate-specific antigen (PSA) level after radical prostatectomy. METHODS: Forty-five patients were referred for a rising PSA level after radical prostatectomy. Transrectal ultrasound evaluation included visualization of the VUA and VUA quadrant biopsies. The rate of positive biopsies (per core and per patient) was correlated with race, PSA level, and the radical prostatectomy pathologic stage. RESULTS: Overall, 53% of patients had a positive biopsy. In multivariate analysis, the dominant independent and synergistic clinical parameters determining positive biopsy rates were a PSA greater than 1 ng/mL at the time of biopsy and the pathologic stage (P = 0.04 and P = 0.02, respectively). Using a PSA cutoff point of 1.0 ng/mL, those patients with organ-confined disease and a PSA of 1.0 ng/mL or less showed no positive cancer cores (low-risk group). Conversely, 89% of patients with extraprostatic extension and a PSA greater than 1.0 ng/mL had a positive biopsy (P

Original languageEnglish (US)
Pages (from-to)1044-1048
Number of pages5
JournalUrology
Volume54
Issue number6
StatePublished - Dec 1999
Externally publishedYes

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Prostate-Specific Antigen
Prostatectomy
Biopsy
Multivariate Analysis
Neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Shekarriz, B., Upadhyay, J., Wood, D. P., Hinman, J., Raasch, J., Cummings, G. D., ... Littrup, P. J. (1999). Vesicourethral anastomosis biopsy after radical prostatectomy: predictive value of prostate-specific antigen and pathologic stage. Urology, 54(6), 1044-1048.

Vesicourethral anastomosis biopsy after radical prostatectomy : predictive value of prostate-specific antigen and pathologic stage. / Shekarriz, B.; Upadhyay, J.; Wood, D. P.; Hinman, J.; Raasch, J.; Cummings, G. D.; Grignon, David; Littrup, P. J.

In: Urology, Vol. 54, No. 6, 12.1999, p. 1044-1048.

Research output: Contribution to journalArticle

Shekarriz, B, Upadhyay, J, Wood, DP, Hinman, J, Raasch, J, Cummings, GD, Grignon, D & Littrup, PJ 1999, 'Vesicourethral anastomosis biopsy after radical prostatectomy: predictive value of prostate-specific antigen and pathologic stage.', Urology, vol. 54, no. 6, pp. 1044-1048.
Shekarriz B, Upadhyay J, Wood DP, Hinman J, Raasch J, Cummings GD et al. Vesicourethral anastomosis biopsy after radical prostatectomy: predictive value of prostate-specific antigen and pathologic stage. Urology. 1999 Dec;54(6):1044-1048.
Shekarriz, B. ; Upadhyay, J. ; Wood, D. P. ; Hinman, J. ; Raasch, J. ; Cummings, G. D. ; Grignon, David ; Littrup, P. J. / Vesicourethral anastomosis biopsy after radical prostatectomy : predictive value of prostate-specific antigen and pathologic stage. In: Urology. 1999 ; Vol. 54, No. 6. pp. 1044-1048.
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AU - Hinman, J.

AU - Raasch, J.

AU - Cummings, G. D.

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