Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages

Dan Li Xie, Meng Meng Zheng, Yi Zheng, Hui Gao, Jie Zhang, Ting Zhang, Jian Chun Guo, X. Frank Yang, Xiao Ping Zhong, Yong Liang Lou

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4 Scopus citations

Abstract

Vibrio vulnificus (V. vulnificus), a Gram-negative marine bacterium, can cause life-threatening primary septicemia, especially in patients with liver diseases. How V. vulnificus affects the liver and how it acts on macrophages are not well understood. In this report, we demonstrated that V. vulnificus infection causes a strong inflammatory response, marked expansion of liver-resident macrophages, and liver damage in mice. We demonstrated further that V. vulnificus activates mTOR in macrophages and inhibition of mTOR differentially regulates V. vulnificus induced inflammatory responses, suggesting the possibility of targeting mTOR as a strategy to modulate V. vulnificus induced inflammatory responses.

Original languageEnglish (US)
Article numbere0181454
JournalPLoS ONE
Volume12
Issue number7
DOIs
StatePublished - Jul 2017

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Xie, D. L., Zheng, M. M., Zheng, Y., Gao, H., Zhang, J., Zhang, T., Guo, J. C., Yang, X. F., Zhong, X. P., & Lou, Y. L. (2017). Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages. PLoS ONE, 12(7), [e0181454]. https://doi.org/10.1371/journal.pone.0181454