Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages

Dan Li Xie, Meng Meng Zheng, Yi Zheng, Hui Gao, Jie Zhang, Ting Zhang, Jian Chun Guo, X. Yang, Xiao Ping Zhong, Yong Liang Lou

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Vibrio vulnificus (V. vulnificus), a Gram-negative marine bacterium, can cause life-threatening primary septicemia, especially in patients with liver diseases. How V. vulnificus affects the liver and how it acts on macrophages are not well understood. In this report, we demonstrated that V. vulnificus infection causes a strong inflammatory response, marked expansion of liver-resident macrophages, and liver damage in mice. We demonstrated further that V. vulnificus activates mTOR in macrophages and inhibition of mTOR differentially regulates V. vulnificus induced inflammatory responses, suggesting the possibility of targeting mTOR as a strategy to modulate V. vulnificus induced inflammatory responses.

Original languageEnglish (US)
Article numbere0181454
JournalPLoS One
Volume12
Issue number7
DOIs
StatePublished - Jul 1 2017

Fingerprint

Vibrio vulnificus
Macrophages
Liver
macrophages
inflammation
Chemical activation
liver
Bacteria
Gram-Negative Bacteria
septicemia
liver diseases
Liver Diseases
Sepsis
bacteria
mice
infection

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Xie, D. L., Zheng, M. M., Zheng, Y., Gao, H., Zhang, J., Zhang, T., ... Lou, Y. L. (2017). Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages. PLoS One, 12(7), [e0181454]. https://doi.org/10.1371/journal.pone.0181454

Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages. / Xie, Dan Li; Zheng, Meng Meng; Zheng, Yi; Gao, Hui; Zhang, Jie; Zhang, Ting; Guo, Jian Chun; Yang, X.; Zhong, Xiao Ping; Lou, Yong Liang.

In: PLoS One, Vol. 12, No. 7, e0181454, 01.07.2017.

Research output: Contribution to journalArticle

Xie, DL, Zheng, MM, Zheng, Y, Gao, H, Zhang, J, Zhang, T, Guo, JC, Yang, X, Zhong, XP & Lou, YL 2017, 'Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages', PLoS One, vol. 12, no. 7, e0181454. https://doi.org/10.1371/journal.pone.0181454
Xie DL, Zheng MM, Zheng Y, Gao H, Zhang J, Zhang T et al. Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages. PLoS One. 2017 Jul 1;12(7). e0181454. https://doi.org/10.1371/journal.pone.0181454
Xie, Dan Li ; Zheng, Meng Meng ; Zheng, Yi ; Gao, Hui ; Zhang, Jie ; Zhang, Ting ; Guo, Jian Chun ; Yang, X. ; Zhong, Xiao Ping ; Lou, Yong Liang. / Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages. In: PLoS One. 2017 ; Vol. 12, No. 7.
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