Viral upper respiratory tract infection and otitis media complication in young children

Tasnee Chonmaitree, Krystal Revai, James J. Grady, Audra Clos, Janak A. Patel, Sangeeta Nair, Jiang Fan, Kelly J. Henrickson

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Background. The common cold or upper respiratory infection (URI) is highly prevalent among young children and often results in otitis media (OM). The incidence and characteristics of OM complicating URI due to specific viruses have not been well studied. Methods. We performed a prospective, longitudinal cohort study of 294 healthy children (age range, 6 months to 3 years). Each child was observed for 1 year to assess the occurrence of URI, acute OM (AOM), and OM with effusion (OME) complicating URI due to specific viruses. Results. We documented 1295 URI episodes (5.06 episodes per child-year) and 440 AOM episodes (1.72 episodes per child-year). Virus studies were performed for 864 URI episodes; 63% were virus positive. Rhinovirus and adenovirus were most frequently detected during URI. The overall incidence of OM that complicated URI was 61%, including a 37% incidence of AOM and a 24% incidence of OME. Young age was the most important predictor of AOM that complicated URI. AOM occurred in approximately one-half of children with URI due to adenovirus, respiratory syncytial virus, or coronavirus and in approximately one-third of those with URI due to influenza virus, parainfluenza virus, enterovirus, or rhinovirus. Conclusions. More than 60% of episodes of symptomatic URI among young children were complicated by AOM and/or OME. Young age and specific virus types were predictors of URI complicated by AOM. For young children, the strategy to prevent OM should involve prevention of viral URI. The strategy may be more effective if the priority is given to development of means to prevent URI associated with adenovirus and respiratory syncytial virus.

Original languageEnglish (US)
Pages (from-to)815-823
Number of pages9
JournalClinical Infectious Diseases
Volume46
Issue number6
DOIs
StatePublished - Mar 15 2008
Externally publishedYes

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Otitis Media
Respiratory Tract Infections
Viruses
Adenoviridae
Rhinovirus
Respiratory Syncytial Viruses
Incidence
Paramyxoviridae Infections
Common Cold
Otitis Media with Effusion
Coronavirus
Enterovirus
Orthomyxoviridae
Longitudinal Studies

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

Chonmaitree, T., Revai, K., Grady, J. J., Clos, A., Patel, J. A., Nair, S., ... Henrickson, K. J. (2008). Viral upper respiratory tract infection and otitis media complication in young children. Clinical Infectious Diseases, 46(6), 815-823. https://doi.org/10.1086/528685

Viral upper respiratory tract infection and otitis media complication in young children. / Chonmaitree, Tasnee; Revai, Krystal; Grady, James J.; Clos, Audra; Patel, Janak A.; Nair, Sangeeta; Fan, Jiang; Henrickson, Kelly J.

In: Clinical Infectious Diseases, Vol. 46, No. 6, 15.03.2008, p. 815-823.

Research output: Contribution to journalArticle

Chonmaitree, T, Revai, K, Grady, JJ, Clos, A, Patel, JA, Nair, S, Fan, J & Henrickson, KJ 2008, 'Viral upper respiratory tract infection and otitis media complication in young children', Clinical Infectious Diseases, vol. 46, no. 6, pp. 815-823. https://doi.org/10.1086/528685
Chonmaitree T, Revai K, Grady JJ, Clos A, Patel JA, Nair S et al. Viral upper respiratory tract infection and otitis media complication in young children. Clinical Infectious Diseases. 2008 Mar 15;46(6):815-823. https://doi.org/10.1086/528685
Chonmaitree, Tasnee ; Revai, Krystal ; Grady, James J. ; Clos, Audra ; Patel, Janak A. ; Nair, Sangeeta ; Fan, Jiang ; Henrickson, Kelly J. / Viral upper respiratory tract infection and otitis media complication in young children. In: Clinical Infectious Diseases. 2008 ; Vol. 46, No. 6. pp. 815-823.
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abstract = "Background. The common cold or upper respiratory infection (URI) is highly prevalent among young children and often results in otitis media (OM). The incidence and characteristics of OM complicating URI due to specific viruses have not been well studied. Methods. We performed a prospective, longitudinal cohort study of 294 healthy children (age range, 6 months to 3 years). Each child was observed for 1 year to assess the occurrence of URI, acute OM (AOM), and OM with effusion (OME) complicating URI due to specific viruses. Results. We documented 1295 URI episodes (5.06 episodes per child-year) and 440 AOM episodes (1.72 episodes per child-year). Virus studies were performed for 864 URI episodes; 63{\%} were virus positive. Rhinovirus and adenovirus were most frequently detected during URI. The overall incidence of OM that complicated URI was 61{\%}, including a 37{\%} incidence of AOM and a 24{\%} incidence of OME. Young age was the most important predictor of AOM that complicated URI. AOM occurred in approximately one-half of children with URI due to adenovirus, respiratory syncytial virus, or coronavirus and in approximately one-third of those with URI due to influenza virus, parainfluenza virus, enterovirus, or rhinovirus. Conclusions. More than 60{\%} of episodes of symptomatic URI among young children were complicated by AOM and/or OME. Young age and specific virus types were predictors of URI complicated by AOM. For young children, the strategy to prevent OM should involve prevention of viral URI. The strategy may be more effective if the priority is given to development of means to prevent URI associated with adenovirus and respiratory syncytial virus.",
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AU - Grady, James J.

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AU - Patel, Janak A.

AU - Nair, Sangeeta

AU - Fan, Jiang

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N2 - Background. The common cold or upper respiratory infection (URI) is highly prevalent among young children and often results in otitis media (OM). The incidence and characteristics of OM complicating URI due to specific viruses have not been well studied. Methods. We performed a prospective, longitudinal cohort study of 294 healthy children (age range, 6 months to 3 years). Each child was observed for 1 year to assess the occurrence of URI, acute OM (AOM), and OM with effusion (OME) complicating URI due to specific viruses. Results. We documented 1295 URI episodes (5.06 episodes per child-year) and 440 AOM episodes (1.72 episodes per child-year). Virus studies were performed for 864 URI episodes; 63% were virus positive. Rhinovirus and adenovirus were most frequently detected during URI. The overall incidence of OM that complicated URI was 61%, including a 37% incidence of AOM and a 24% incidence of OME. Young age was the most important predictor of AOM that complicated URI. AOM occurred in approximately one-half of children with URI due to adenovirus, respiratory syncytial virus, or coronavirus and in approximately one-third of those with URI due to influenza virus, parainfluenza virus, enterovirus, or rhinovirus. Conclusions. More than 60% of episodes of symptomatic URI among young children were complicated by AOM and/or OME. Young age and specific virus types were predictors of URI complicated by AOM. For young children, the strategy to prevent OM should involve prevention of viral URI. The strategy may be more effective if the priority is given to development of means to prevent URI associated with adenovirus and respiratory syncytial virus.

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