Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK

Gourapura J. Renukaradhya, Tonya J Roberts Webb, Masood A. Khan, Yin Ling Lin, Wenjun Du, Jacquelyn Gervay-Hague, Randy Brutkiewicz

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

A critical component of the host's innate immune response involves lipid Ag presentation by CD1d molecules to NK T cells. In this study we used murine CD1d1-transfected L (L-CD1) cells to study the effect of viruses on CD1d-mediated Ag presentation to NKT cells and found that an infection with vesicular stomatitis and vaccinia (but not lymphocytic choriomeningitis) virus inhibited murine CD1d1-mediated Ag presentation. This was under the reciprocal control of the MAPKs, p38 and ERK, and was due to changes in the intracellular trafficking of CD1d1. The reciprocal regulation of CD1d1-mediatcd Ag presentation by MAPK suggests that the targeting of these pathways is a novel means of immune evasion by viruses.

Original languageEnglish
Pages (from-to)4301-4308
Number of pages8
JournalJournal of Immunology
Volume175
Issue number7
StatePublished - Oct 1 2005

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Antigen Presentation
CD1d Antigen
Viruses
Lymphocytic choriomeningitis virus
Immune Evasion
Vaccinia
Vesicular Stomatitis
Natural Killer T-Cells
p38 Mitogen-Activated Protein Kinases
Innate Immunity
Natural Killer Cells
T-Lymphocytes
Lipids
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Renukaradhya, G. J., Webb, T. J. R., Khan, M. A., Lin, Y. L., Du, W., Gervay-Hague, J., & Brutkiewicz, R. (2005). Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK. Journal of Immunology, 175(7), 4301-4308.

Virus-induced inhibition of CD1d1-mediated antigen presentation : Reciprocal regulation by p38 and ERK. / Renukaradhya, Gourapura J.; Webb, Tonya J Roberts; Khan, Masood A.; Lin, Yin Ling; Du, Wenjun; Gervay-Hague, Jacquelyn; Brutkiewicz, Randy.

In: Journal of Immunology, Vol. 175, No. 7, 01.10.2005, p. 4301-4308.

Research output: Contribution to journalArticle

Renukaradhya, GJ, Webb, TJR, Khan, MA, Lin, YL, Du, W, Gervay-Hague, J & Brutkiewicz, R 2005, 'Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK', Journal of Immunology, vol. 175, no. 7, pp. 4301-4308.
Renukaradhya GJ, Webb TJR, Khan MA, Lin YL, Du W, Gervay-Hague J et al. Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK. Journal of Immunology. 2005 Oct 1;175(7):4301-4308.
Renukaradhya, Gourapura J. ; Webb, Tonya J Roberts ; Khan, Masood A. ; Lin, Yin Ling ; Du, Wenjun ; Gervay-Hague, Jacquelyn ; Brutkiewicz, Randy. / Virus-induced inhibition of CD1d1-mediated antigen presentation : Reciprocal regulation by p38 and ERK. In: Journal of Immunology. 2005 ; Vol. 175, No. 7. pp. 4301-4308.
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