Visual contrast sensitivity in Alzheimer's disease, mild cognitive impairment, and older adults with cognitive complaints

Shannon L. Risacher, Darrell WuDunn, Susan M. Pepin, Tamiko R. MaGee, Brenna McDonald, Laura A. Flashman, Heather A. Wishart, Heather S. Pixley, Laura A. Rabin, Nadia Paré, Jessica J. Englert, Eben Schwartz, Joshua R. Curtain, John D. West, Darren P. O'Neill, Robert B. Santulli, Richard W. Newman, Andrew Saykin

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Deficits in contrast sensitivity (CS) have been reported in Alzheimer's disease (AD). However, the extent of these deficits in prodromal AD stages, including mild cognitive impairment (MCI) or even earlier, has not been investigated. In this study, CS was assessed using frequency doubling technology in older adults with AD (n = 10), amnestic MCI (n = 28), cognitive complaints without performance deficits (CC; n = 20), and healthy controls (HC; n = 29). The association between CS and cognition was also evaluated. Finally, the accuracy of CS measures for classifying MCI versus HC was evaluated. CS deficits were found in AD and MCI, while CC showed intermediate performance between MCI and HC. Upper right visual field CS showed the most significant difference among groups. CS was also associated with cognitive performance. Finally, CS measures accurately classified MCI versus HC. The CS deficits in AD and MCI, and intermediate performance in CC, indicate that these measures are sensitive to early AD-associated changes. Therefore, frequency doubling technology-based measures of CS may have promise as a novel AD biomarker.

Original languageEnglish
Pages (from-to)1133-1144
Number of pages12
JournalNeurobiology of Aging
Volume34
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Contrast Sensitivity
Alzheimer Disease
Cognitive Dysfunction
Technology
Visual Fields
Cognition
Biomarkers

Keywords

  • Alzheimer's disease (AD)
  • Biomarker
  • Cognitive complaints
  • Contrast sensitivity (CS)
  • Frequency doubling technology (FDT)
  • Mild cognitive impairment (MCI)
  • Vision

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Visual contrast sensitivity in Alzheimer's disease, mild cognitive impairment, and older adults with cognitive complaints. / Risacher, Shannon L.; WuDunn, Darrell; Pepin, Susan M.; MaGee, Tamiko R.; McDonald, Brenna; Flashman, Laura A.; Wishart, Heather A.; Pixley, Heather S.; Rabin, Laura A.; Paré, Nadia; Englert, Jessica J.; Schwartz, Eben; Curtain, Joshua R.; West, John D.; O'Neill, Darren P.; Santulli, Robert B.; Newman, Richard W.; Saykin, Andrew.

In: Neurobiology of Aging, Vol. 34, No. 4, 04.2013, p. 1133-1144.

Research output: Contribution to journalArticle

Risacher, SL, WuDunn, D, Pepin, SM, MaGee, TR, McDonald, B, Flashman, LA, Wishart, HA, Pixley, HS, Rabin, LA, Paré, N, Englert, JJ, Schwartz, E, Curtain, JR, West, JD, O'Neill, DP, Santulli, RB, Newman, RW & Saykin, A 2013, 'Visual contrast sensitivity in Alzheimer's disease, mild cognitive impairment, and older adults with cognitive complaints', Neurobiology of Aging, vol. 34, no. 4, pp. 1133-1144. https://doi.org/10.1016/j.neurobiolaging.2012.08.007
Risacher, Shannon L. ; WuDunn, Darrell ; Pepin, Susan M. ; MaGee, Tamiko R. ; McDonald, Brenna ; Flashman, Laura A. ; Wishart, Heather A. ; Pixley, Heather S. ; Rabin, Laura A. ; Paré, Nadia ; Englert, Jessica J. ; Schwartz, Eben ; Curtain, Joshua R. ; West, John D. ; O'Neill, Darren P. ; Santulli, Robert B. ; Newman, Richard W. ; Saykin, Andrew. / Visual contrast sensitivity in Alzheimer's disease, mild cognitive impairment, and older adults with cognitive complaints. In: Neurobiology of Aging. 2013 ; Vol. 34, No. 4. pp. 1133-1144.
@article{c1736d6782224a7f96f3b67e632e6960,
title = "Visual contrast sensitivity in Alzheimer's disease, mild cognitive impairment, and older adults with cognitive complaints",
abstract = "Deficits in contrast sensitivity (CS) have been reported in Alzheimer's disease (AD). However, the extent of these deficits in prodromal AD stages, including mild cognitive impairment (MCI) or even earlier, has not been investigated. In this study, CS was assessed using frequency doubling technology in older adults with AD (n = 10), amnestic MCI (n = 28), cognitive complaints without performance deficits (CC; n = 20), and healthy controls (HC; n = 29). The association between CS and cognition was also evaluated. Finally, the accuracy of CS measures for classifying MCI versus HC was evaluated. CS deficits were found in AD and MCI, while CC showed intermediate performance between MCI and HC. Upper right visual field CS showed the most significant difference among groups. CS was also associated with cognitive performance. Finally, CS measures accurately classified MCI versus HC. The CS deficits in AD and MCI, and intermediate performance in CC, indicate that these measures are sensitive to early AD-associated changes. Therefore, frequency doubling technology-based measures of CS may have promise as a novel AD biomarker.",
keywords = "Alzheimer's disease (AD), Biomarker, Cognitive complaints, Contrast sensitivity (CS), Frequency doubling technology (FDT), Mild cognitive impairment (MCI), Vision",
author = "Risacher, {Shannon L.} and Darrell WuDunn and Pepin, {Susan M.} and MaGee, {Tamiko R.} and Brenna McDonald and Flashman, {Laura A.} and Wishart, {Heather A.} and Pixley, {Heather S.} and Rabin, {Laura A.} and Nadia Par{\'e} and Englert, {Jessica J.} and Eben Schwartz and Curtain, {Joshua R.} and West, {John D.} and O'Neill, {Darren P.} and Santulli, {Robert B.} and Newman, {Richard W.} and Andrew Saykin",
year = "2013",
month = "4",
doi = "10.1016/j.neurobiolaging.2012.08.007",
language = "English",
volume = "34",
pages = "1133--1144",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Visual contrast sensitivity in Alzheimer's disease, mild cognitive impairment, and older adults with cognitive complaints

AU - Risacher, Shannon L.

AU - WuDunn, Darrell

AU - Pepin, Susan M.

AU - MaGee, Tamiko R.

AU - McDonald, Brenna

AU - Flashman, Laura A.

AU - Wishart, Heather A.

AU - Pixley, Heather S.

AU - Rabin, Laura A.

AU - Paré, Nadia

AU - Englert, Jessica J.

AU - Schwartz, Eben

AU - Curtain, Joshua R.

AU - West, John D.

AU - O'Neill, Darren P.

AU - Santulli, Robert B.

AU - Newman, Richard W.

AU - Saykin, Andrew

PY - 2013/4

Y1 - 2013/4

N2 - Deficits in contrast sensitivity (CS) have been reported in Alzheimer's disease (AD). However, the extent of these deficits in prodromal AD stages, including mild cognitive impairment (MCI) or even earlier, has not been investigated. In this study, CS was assessed using frequency doubling technology in older adults with AD (n = 10), amnestic MCI (n = 28), cognitive complaints without performance deficits (CC; n = 20), and healthy controls (HC; n = 29). The association between CS and cognition was also evaluated. Finally, the accuracy of CS measures for classifying MCI versus HC was evaluated. CS deficits were found in AD and MCI, while CC showed intermediate performance between MCI and HC. Upper right visual field CS showed the most significant difference among groups. CS was also associated with cognitive performance. Finally, CS measures accurately classified MCI versus HC. The CS deficits in AD and MCI, and intermediate performance in CC, indicate that these measures are sensitive to early AD-associated changes. Therefore, frequency doubling technology-based measures of CS may have promise as a novel AD biomarker.

AB - Deficits in contrast sensitivity (CS) have been reported in Alzheimer's disease (AD). However, the extent of these deficits in prodromal AD stages, including mild cognitive impairment (MCI) or even earlier, has not been investigated. In this study, CS was assessed using frequency doubling technology in older adults with AD (n = 10), amnestic MCI (n = 28), cognitive complaints without performance deficits (CC; n = 20), and healthy controls (HC; n = 29). The association between CS and cognition was also evaluated. Finally, the accuracy of CS measures for classifying MCI versus HC was evaluated. CS deficits were found in AD and MCI, while CC showed intermediate performance between MCI and HC. Upper right visual field CS showed the most significant difference among groups. CS was also associated with cognitive performance. Finally, CS measures accurately classified MCI versus HC. The CS deficits in AD and MCI, and intermediate performance in CC, indicate that these measures are sensitive to early AD-associated changes. Therefore, frequency doubling technology-based measures of CS may have promise as a novel AD biomarker.

KW - Alzheimer's disease (AD)

KW - Biomarker

KW - Cognitive complaints

KW - Contrast sensitivity (CS)

KW - Frequency doubling technology (FDT)

KW - Mild cognitive impairment (MCI)

KW - Vision

UR - http://www.scopus.com/inward/record.url?scp=84872329712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872329712&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2012.08.007

DO - 10.1016/j.neurobiolaging.2012.08.007

M3 - Article

C2 - 23084085

AN - SCOPUS:84872329712

VL - 34

SP - 1133

EP - 1144

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 4

ER -