Visual Event-Related Potentials in Schizotypal Personality Disorder and Schizophrenia

Jenifer L. Vohs, William P. Hetrick, Paul D. Kieffaber, Misty Bodkins, Andrew Bismark, Anantha Shekhar, Brian F. O'Donnell

Research output: Contribution to journalArticle

12 Scopus citations


Schizophrenia (SZ) occurs among a spectrum of disorders with similar characteristics, including schizotypal personality disorder (SPD). Visual processing disturbances have been reported in both disorders, but it is not yet clear which processes are disturbed in both SZ and SPD, suggestive of a common endophenotype, and which appear only in SZ. In order to address this question, the authors evaluated visual event-related potentials (ERPs) elicited during a line-orientation discrimination task in control, SPD, and SZ participants. Visual ERPs allow specification of both the time course and physiological correlates of visual perception and cognition. SZ patients had smaller P100 and P300a amplitudes and prolonged P300b latency compared to the control group. SZ patients also had smaller N160, N200, P300a, and P300b amplitudes compared to the SPD group. SPD participants did not differ from control participants on any ERP measure. These data documented pervasive abnormalities in visual perception and attention in SZ but not in SPD, suggesting that these visual ERP disturbances may not represent a common endophenotype.

Original languageEnglish (US)
Pages (from-to)119-131
Number of pages13
JournalJournal of Abnormal Psychology
Issue number1
StatePublished - Feb 2008


  • event-related potentials
  • P300
  • schizophrenia
  • schizotypal personality disorder
  • visual

ASJC Scopus subject areas

  • Clinical Psychology
  • Experimental and Cognitive Psychology
  • Psychology(all)

Fingerprint Dive into the research topics of 'Visual Event-Related Potentials in Schizotypal Personality Disorder and Schizophrenia'. Together they form a unique fingerprint.

Cite this