Visual field defects after radiosurgery for mesial temporal lobe epilepsy

Holly Hensley-Judge, Mark Quigg, Nicholas Barbaro, Steven A. Newman, Mariann M. Ward, Edward F. Chang, Donna K. Broshek, Kathleen R. Lamborn, Kenneth D. Laxer, Paul Garcia, Christianne N. Heck, Douglas Kondziolka, Robert Beach, Vicenta Salanova, Robert Goodman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose Gamma knife radiosurgery (RS) may be an alternative to open surgery for mesial temporal lobe epilepsy (MTLE), but morbidities and the anticonvulsant mechanisms of RS are unclear. Examination of visual field defects (VFDs) after RS may provide evidence of the extent of a postoperative fixed lesion. VFDs occur in 52-100% of patients following open surgery for MTLE. Methods This multicenter prospective trial of RS enrolled patients with unilateral hippocampal sclerosis and concordant video-electroencephalography (EEG) findings. Patients were randomized to low (20 Gy) or high (24 Gy) doses delivered to the amygdala, hippocampal head, and parahippocampal gyrus. Postoperative perimetry were obtained at 24 months after RS. Visual field defect ratios (VFDRs) were calculated to quantify the degree of VFDs. Results were contrasted with age, RS dose and 50% isodose volume, peak volume of radiation-induced change at the surgical target, quality of life measurements, and seizure remission. Key Findings No patients reported visual changes and no patients had abnormal bedside visual field examinations. Fifteen (62.5%) of 24 patients had postoperative VFDs, all homonymous superior quadrantanopsias. None of the VFDs were consistent with injury to the optic nerve or chiasm. Clinical diagnosis of VFDs correlated significantly with VFDRs (p = 0.0005). Patients with seizure remission had smaller (more severe) VFDRs (p = 0.04). No other variables had significant correlations. Significance VFDs appeared after RS in proportions similar to historical comparisons from open surgery for MTLE. The nature of VFDs was consistent with lesions of the optic radiations. The findings support the hypothesis that the mechanism of RS involves some degree of tissue damage and is not confined entirely to functional changes in neuromodulation.

Original languageEnglish
Pages (from-to)1376-1380
Number of pages5
JournalEpilepsia
Volume54
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

Temporal Lobe Epilepsy
Radiosurgery
Visual Fields
Parahippocampal Gyrus
Seizures
Radiation
Optic Chiasm
Visual Field Tests
Sclerosis
Amygdala
Anticonvulsants
Multicenter Studies
Electroencephalography
Head
Quality of Life

Keywords

  • Epilepsy surgery
  • Gamma knife
  • Mesial temporal lobe epilepsy
  • Partial seizures
  • Radiosurgery
  • Visual field defects

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Hensley-Judge, H., Quigg, M., Barbaro, N., Newman, S. A., Ward, M. M., Chang, E. F., ... Goodman, R. (2013). Visual field defects after radiosurgery for mesial temporal lobe epilepsy. Epilepsia, 54(8), 1376-1380. https://doi.org/10.1111/epi.12215

Visual field defects after radiosurgery for mesial temporal lobe epilepsy. / Hensley-Judge, Holly; Quigg, Mark; Barbaro, Nicholas; Newman, Steven A.; Ward, Mariann M.; Chang, Edward F.; Broshek, Donna K.; Lamborn, Kathleen R.; Laxer, Kenneth D.; Garcia, Paul; Heck, Christianne N.; Kondziolka, Douglas; Beach, Robert; Salanova, Vicenta; Goodman, Robert.

In: Epilepsia, Vol. 54, No. 8, 08.2013, p. 1376-1380.

Research output: Contribution to journalArticle

Hensley-Judge, H, Quigg, M, Barbaro, N, Newman, SA, Ward, MM, Chang, EF, Broshek, DK, Lamborn, KR, Laxer, KD, Garcia, P, Heck, CN, Kondziolka, D, Beach, R, Salanova, V & Goodman, R 2013, 'Visual field defects after radiosurgery for mesial temporal lobe epilepsy', Epilepsia, vol. 54, no. 8, pp. 1376-1380. https://doi.org/10.1111/epi.12215
Hensley-Judge H, Quigg M, Barbaro N, Newman SA, Ward MM, Chang EF et al. Visual field defects after radiosurgery for mesial temporal lobe epilepsy. Epilepsia. 2013 Aug;54(8):1376-1380. https://doi.org/10.1111/epi.12215
Hensley-Judge, Holly ; Quigg, Mark ; Barbaro, Nicholas ; Newman, Steven A. ; Ward, Mariann M. ; Chang, Edward F. ; Broshek, Donna K. ; Lamborn, Kathleen R. ; Laxer, Kenneth D. ; Garcia, Paul ; Heck, Christianne N. ; Kondziolka, Douglas ; Beach, Robert ; Salanova, Vicenta ; Goodman, Robert. / Visual field defects after radiosurgery for mesial temporal lobe epilepsy. In: Epilepsia. 2013 ; Vol. 54, No. 8. pp. 1376-1380.
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abstract = "Purpose Gamma knife radiosurgery (RS) may be an alternative to open surgery for mesial temporal lobe epilepsy (MTLE), but morbidities and the anticonvulsant mechanisms of RS are unclear. Examination of visual field defects (VFDs) after RS may provide evidence of the extent of a postoperative fixed lesion. VFDs occur in 52-100{\%} of patients following open surgery for MTLE. Methods This multicenter prospective trial of RS enrolled patients with unilateral hippocampal sclerosis and concordant video-electroencephalography (EEG) findings. Patients were randomized to low (20 Gy) or high (24 Gy) doses delivered to the amygdala, hippocampal head, and parahippocampal gyrus. Postoperative perimetry were obtained at 24 months after RS. Visual field defect ratios (VFDRs) were calculated to quantify the degree of VFDs. Results were contrasted with age, RS dose and 50{\%} isodose volume, peak volume of radiation-induced change at the surgical target, quality of life measurements, and seizure remission. Key Findings No patients reported visual changes and no patients had abnormal bedside visual field examinations. Fifteen (62.5{\%}) of 24 patients had postoperative VFDs, all homonymous superior quadrantanopsias. None of the VFDs were consistent with injury to the optic nerve or chiasm. Clinical diagnosis of VFDs correlated significantly with VFDRs (p = 0.0005). Patients with seizure remission had smaller (more severe) VFDRs (p = 0.04). No other variables had significant correlations. Significance VFDs appeared after RS in proportions similar to historical comparisons from open surgery for MTLE. The nature of VFDs was consistent with lesions of the optic radiations. The findings support the hypothesis that the mechanism of RS involves some degree of tissue damage and is not confined entirely to functional changes in neuromodulation.",
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