Visual hallucination and tremor induced by sertraline and oxycodone in a bone marrow transplant patient

C. J. Rosebraugh, D. A. Flockhart, S. U. Yasuda, R. L. Woosley

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The authors report a case of probable serotonin syndrome caused by the coadministration of sertraline and oxycodone. A 34 year-old male patient experienced visual hallucinations and severe tremor after dramatically increasing his dosage of oxycodone while on stable amounts of sertraline and cyclosporin. Discontinuation of cyclosporin did not result in resolution of his symptoms. Consideration of a possible sertraline-oxycodone interaction led to withholding sertraline, which resulted in symptom resolution. Serotonin syndrome has been noted with sertraline in combination with other drugs, but this is the first report in combination with a narcotic analgesic. Possible pharmacological mechanisms are discussed. In complicated patients that are taking multiple medications, physicians should be aware of this possible interaction to avoid delay in the diagnosis of serotonin syndrome.

Original languageEnglish (US)
Pages (from-to)224-227
Number of pages4
JournalJournal of clinical pharmacology
Volume41
Issue number2
DOIs
StatePublished - Feb 8 2001

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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