Visual Object Agnosia and Pure Word Alexia: Correlation of Functional Magnetic Resonance Imaging and Lesion Localization

Carmen V. Salvan, John L. Ulmer, Edgar A. DeYoe, Thomas Wascher, Vincent Mathews, James W. Lewis, Robert W. Prost

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We present a case of a 64-year-old, right-handed female with a metastatic breast cancer lesion involving the left posterior inferior temporal lobe causing complete loss of the ability to recognize visually common objects and words. After her symptoms resolved on corticosteroid therapy, functional magnetic resonance imaging (fMRI) mapping demonstrated strong left-hemispheric dominance for word recognition and right-hemispheric dominance for object recognition. The case illustrates the relationships among ventral occipito-temporal cortical activation, lesion localization, and lesion-induced deficits of higher visual function. The relationship between hemispheric dominance determined by fMRI and risk of postoperative deficit depends on the specific visual function of interest.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalJournal of Computer Assisted Tomography
Volume28
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Pure Alexia
Agnosia
Magnetic Resonance Imaging
Aptitude
Temporal Lobe
Adrenal Cortex Hormones
Breast Neoplasms
Therapeutics

Keywords

  • Bold oxygen level dependent (BOLD)
  • Functional magnetic resonance imaging (fMRI)
  • Object recognition
  • Ventral occipito-temporal cortex (VOTC)
  • Word recognition

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Visual Object Agnosia and Pure Word Alexia : Correlation of Functional Magnetic Resonance Imaging and Lesion Localization. / Salvan, Carmen V.; Ulmer, John L.; DeYoe, Edgar A.; Wascher, Thomas; Mathews, Vincent; Lewis, James W.; Prost, Robert W.

In: Journal of Computer Assisted Tomography, Vol. 28, No. 1, 01.2004, p. 63-67.

Research output: Contribution to journalArticle

Salvan, Carmen V. ; Ulmer, John L. ; DeYoe, Edgar A. ; Wascher, Thomas ; Mathews, Vincent ; Lewis, James W. ; Prost, Robert W. / Visual Object Agnosia and Pure Word Alexia : Correlation of Functional Magnetic Resonance Imaging and Lesion Localization. In: Journal of Computer Assisted Tomography. 2004 ; Vol. 28, No. 1. pp. 63-67.
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