Visualization of myocardial infarction and subsequent coronary reperfusion with MRI using a dog model

Alex M. Aisen, Andrew J. Buda, Rainer J. Zotz, Kenneth Buckwalter

Research output: Contribution to journalArticle

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Abstract

Twelve anesthetized mongrel dogs underwent left thoracotomy with placement of a removable ligature around the left circumflex coronary artery. Following a 3 to 6 hour delay, ECG-gated spin-echo MRI was performed. The ligature was then removed reperfusing the heart, and after a 10-15 min period, MRI repeated. Finally, post-sacrifice images were obtained, and the hearts chemically stained for infarct evaluation. The MR images were subjectively and quantitatively evaluated for visibility of the endocardial border and of the injured myocardium, and for changes after reperfusion. The injured tissue was variably visible in vivo, the major limitation a result of motion blurring and artifact. The abnormal tissue was easily visible on MRI in 11 animals, and not clearly visible in one. The endocardial border was easily seen in 10 animals. The variation of calculated relaxation times was high for both normal and ischemic/infarcted myocardium in the beating hearts (normal: T1 = 566 ± 288, T2 = 38 ± 6; injured myocardium: T1 = 637 ± 250, T2 = 41 ± 12) in contrast, relatively stationary skeletal muscle measured in the same images had narrower ranges (T1 = 532 ± 199, T2 = 28 ± 2). Changes with reperfusion were seen, but not reliably. The infarcted or ischemic zones were easily visible on post-sacrifice images in all animals imaged. Post-sacrifice relaxation times were T1 = 564 ± 69 msec, T2 = 39 ± 3 msec for normal heart muscle, and 725 ± 114, T2 = 47 ± 5 for ischemic/infarcted tissue. We conclude that acute myocardial infarction can usually be detected by MRI, given a prior knowledge of its location. However, the technique is at present likely to be of only limited value clinically in the prospective diagnosis of acute myocardial infarction, though this may improve as technology advances. Finally, signal changes following reperfusion may be visible in some cases, but not reliably so.

Original languageEnglish (US)
Pages (from-to)399-404
Number of pages6
JournalMagnetic Resonance Imaging
Volume5
Issue number5
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

myocardial infarction
Myocardial Reperfusion
dogs
myocardium
Magnetic resonance imaging
Myocardium
Visualization
Myocardial Infarction
Dogs
Reperfusion
animals
Animals
Tissue
borders
Relaxation time
Ligation
Muscle
relaxation time
skeletal muscle
blurring

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Visualization of myocardial infarction and subsequent coronary reperfusion with MRI using a dog model. / Aisen, Alex M.; Buda, Andrew J.; Zotz, Rainer J.; Buckwalter, Kenneth.

In: Magnetic Resonance Imaging, Vol. 5, No. 5, 1987, p. 399-404.

Research output: Contribution to journalArticle

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abstract = "Twelve anesthetized mongrel dogs underwent left thoracotomy with placement of a removable ligature around the left circumflex coronary artery. Following a 3 to 6 hour delay, ECG-gated spin-echo MRI was performed. The ligature was then removed reperfusing the heart, and after a 10-15 min period, MRI repeated. Finally, post-sacrifice images were obtained, and the hearts chemically stained for infarct evaluation. The MR images were subjectively and quantitatively evaluated for visibility of the endocardial border and of the injured myocardium, and for changes after reperfusion. The injured tissue was variably visible in vivo, the major limitation a result of motion blurring and artifact. The abnormal tissue was easily visible on MRI in 11 animals, and not clearly visible in one. The endocardial border was easily seen in 10 animals. The variation of calculated relaxation times was high for both normal and ischemic/infarcted myocardium in the beating hearts (normal: T1 = 566 ± 288, T2 = 38 ± 6; injured myocardium: T1 = 637 ± 250, T2 = 41 ± 12) in contrast, relatively stationary skeletal muscle measured in the same images had narrower ranges (T1 = 532 ± 199, T2 = 28 ± 2). Changes with reperfusion were seen, but not reliably. The infarcted or ischemic zones were easily visible on post-sacrifice images in all animals imaged. Post-sacrifice relaxation times were T1 = 564 ± 69 msec, T2 = 39 ± 3 msec for normal heart muscle, and 725 ± 114, T2 = 47 ± 5 for ischemic/infarcted tissue. We conclude that acute myocardial infarction can usually be detected by MRI, given a prior knowledge of its location. However, the technique is at present likely to be of only limited value clinically in the prospective diagnosis of acute myocardial infarction, though this may improve as technology advances. Finally, signal changes following reperfusion may be visible in some cases, but not reliably so.",
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