Vitamin D and hyperparathyroidism in obesity

Elizabeth Grethen, Ronald McClintock, Christine E. Gupta, Rose Marie Jones, Brenda M. Cacucci, David Diaz, Angie D. Fulford, Susan M. Perkins, Robert V. Considine, Munro Peacock

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Background: Low vitamin D status and hyperparathyroidism occur in obesity and may be involved in pathogenesis of obesity-associated comorbid conditions. Aims: Our aims were to determine in obesity whether there was vitamin D insufficiency, assessed by serum 25-hydroxyvitamin D (s25D) and serum PTH (sPTH) and whether it related to comorbid conditions. Methods:Weconducted a case-control study of 48 women having bariatric surgery and 50 healthy women frequency matched for race, age, year, and season of study. Height, weight, s25D, sPTH, serum 1,25-dihydroxyvitamin D (s1,25D), serum bone alkaline phosphatase, serum cross-linked N-telopeptides of type 1 collagen, and serum calcium, phosphate, creatinine, glucose, and insulin were measured, and comorbid conditions were documented from patient files. Results: Weight (140 vs. 76 kg, P < 0.001), sPTH (44.4 vs. 25.6 pg/ml, P < 0.001), s1,25D (39 vs. 24 pg/ml, P<0.001), serum bone alkaline phosphatase (19 vs. 12 ng/ml, P<0.001), serum cross-linked N-telopeptides of type 1 collagen (9.6 vs. 7.9 nM bone collagen equivalents, P = 0.007), serum phosphate (3.45 vs. 3.24 mg/dl, P=0.043), and serum creatinine (1.05 vs. 0.87 mg/dl, P<0.001) were higher, and s25D (16 vs. 23 ng/ml, P <.001) was lower in bariatric-surgery women than control women. s25D was lower in bariatric-surgery women than controls in summer (17 vs. 26 ng/ml, P < 0.0001) but not winter (15 vs. 18 ng/ml, P > 0.2). Multiple regression analysis demonstrated that weight predicted s25D (P < 0.001) and sPTH (P = 0.001), but s25D did not predict sPTH or the presence of comorbid conditions except for osteoarthritis. Conclusion:Womenhaving bariatric surgery had lower s25D and higher sPTH. The major determinant of s25D and sPTH was weight. Hyperparathyroidism in obesity did not indicate vitamin D insufficiency. Low s25D was not associated with comorbid conditions, apart from osteoarthritis.

Original languageEnglish (US)
Pages (from-to)1320-1326
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Issue number5
StatePublished - May 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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