Vitamin-D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D.

M. H. Brooks, N. H. Bell, L. Love, P. H. Stern, E. Orfei, Sherry Queener, A. J. Hamstra, H. F. DeLuca

Research output: Contribution to journalArticle

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Abstract

Studies were done to determine the cause for hypocalcemia, secondary hyperparathyroidism, osteomalacia and osteitis fibrosa cystica in a 22-year-old black woman. The patient had normal serum 25-hydroxyvitamin D (14 ng per milliliter) and markedly elevated serum 1,25-dihydroxyvitamin D (137 pg per milliliter). Vitamin D3, 4000 units per day for four weeks, increased the serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D to as high as 29 and 297 pg per milliliter, respectively, and corrected the hypocalcemia and secondary hyperparathyroidism. The results suggest that the disorder results from impaired end-organ response to 1,25-dihydroxyvitamin D. We propose that the entity be called vitamin-D-dependent rickets Type II.

Original languageEnglish
Pages (from-to)996-999
Number of pages4
JournalNew England Journal of Medicine
Volume298
Issue number18
StatePublished - May 4 1978
Externally publishedYes

Fingerprint

Rickets
Vitamin D
Secondary Hyperparathyroidism
Hypocalcemia
Osteitis Fibrosa Cystica
Serum
Osteomalacia
Cholecalciferol
1,25-dihydroxyvitamin D
25-hydroxyvitamin D

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Brooks, M. H., Bell, N. H., Love, L., Stern, P. H., Orfei, E., Queener, S., ... DeLuca, H. F. (1978). Vitamin-D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D. New England Journal of Medicine, 298(18), 996-999.

Vitamin-D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D. / Brooks, M. H.; Bell, N. H.; Love, L.; Stern, P. H.; Orfei, E.; Queener, Sherry; Hamstra, A. J.; DeLuca, H. F.

In: New England Journal of Medicine, Vol. 298, No. 18, 04.05.1978, p. 996-999.

Research output: Contribution to journalArticle

Brooks, MH, Bell, NH, Love, L, Stern, PH, Orfei, E, Queener, S, Hamstra, AJ & DeLuca, HF 1978, 'Vitamin-D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D.', New England Journal of Medicine, vol. 298, no. 18, pp. 996-999.
Brooks, M. H. ; Bell, N. H. ; Love, L. ; Stern, P. H. ; Orfei, E. ; Queener, Sherry ; Hamstra, A. J. ; DeLuca, H. F. / Vitamin-D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D. In: New England Journal of Medicine. 1978 ; Vol. 298, No. 18. pp. 996-999.
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