Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria

Sarah E. Cusick, Robert O. Opoka, Troy C. Lund, Chandy John, Lynda E. Polgreen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Vitamin D plays an increasingly recognized role in the innate and adaptive immune response to infection. Based on demonstrated roles in up-regulating innate immunity, decreasing inflammation, and reducing the severity of disease in illnesses such as tuberculosis and influenza, we hypothesized that poor vitamin D status would be associated with severe malaria. We measured 25-hydroxyvitamin D [25(OH)D] by immunoassay in a sample of Ugandan children aged 18 months - 12 years with severe malaria (cerebral malaria or severe malarial anemia, n=40) and in healthy community children (n=20). Ninety-five percent of children with severe malaria (n=38) and 80% of control children (n=16) were vitamin D-insufficient [plasma 25(OH)D

Original languageEnglish (US)
Article numbere113185
JournalPLoS One
Volume9
Issue number12
DOIs
StatePublished - Dec 3 2014
Externally publishedYes

Fingerprint

vitamin D
Vitamin D
malaria
Malaria
Innate Immunity
Cerebral Malaria
Adaptive Immunity
immunoassays
Immunoassay
tuberculosis
influenza
anemia
disease severity
Human Influenza
Plasmas
Anemia
Tuberculosis
inflammation
Inflammation
Infection

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria. / Cusick, Sarah E.; Opoka, Robert O.; Lund, Troy C.; John, Chandy; Polgreen, Lynda E.

In: PLoS One, Vol. 9, No. 12, e113185, 03.12.2014.

Research output: Contribution to journalArticle

Cusick, Sarah E. ; Opoka, Robert O. ; Lund, Troy C. ; John, Chandy ; Polgreen, Lynda E. / Vitamin D insufficiency is common in Ugandan children and is associated with severe malaria. In: PLoS One. 2014 ; Vol. 9, No. 12.
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