Vitamin D resistant hypophosphataemic osteomalacia

treatment with 1α-hydroxyvitamin D3

Munro Peacock, P. J. Heyburn, J. E. Aaron

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

10 Patients with vitamin D resistant hypophosphataemic osteomalacia are described. They had hypophosphataemia with a decreased tubular reabsorption of phosphate, malabsorption of calcium and phosphorus, proximal myopathy and extensive osteomalacic changes on iliac crest bone biopsy. The plasma alkaline phosphatase and urine hydroxyproline, however, were raised in only some of the patients. Treatment with 1α-hydroxyvitamin D3 in high doses rapidly cured the myopathy, increased calcium and phosphorus absorption and retention and healed the osteomalacia. Phosphorus supplements were not required.

Original languageEnglish (US)
JournalClinical Endocrinology
VolumeVol 7, suppl.
StatePublished - 1977
Externally publishedYes

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Osteomalacia
Vitamin D
Phosphorus
Muscular Diseases
Hydroxyproline
Alkaline Phosphatase
Therapeutics
Urine
Calcium
Biopsy
Bone and Bones

ASJC Scopus subject areas

  • Endocrinology

Cite this

Vitamin D resistant hypophosphataemic osteomalacia : treatment with 1α-hydroxyvitamin D3. / Peacock, Munro; Heyburn, P. J.; Aaron, J. E.

In: Clinical Endocrinology, Vol. Vol 7, suppl., 1977.

Research output: Contribution to journalArticle

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abstract = "10 Patients with vitamin D resistant hypophosphataemic osteomalacia are described. They had hypophosphataemia with a decreased tubular reabsorption of phosphate, malabsorption of calcium and phosphorus, proximal myopathy and extensive osteomalacic changes on iliac crest bone biopsy. The plasma alkaline phosphatase and urine hydroxyproline, however, were raised in only some of the patients. Treatment with 1α-hydroxyvitamin D3 in high doses rapidly cured the myopathy, increased calcium and phosphorus absorption and retention and healed the osteomalacia. Phosphorus supplements were not required.",
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PY - 1977

Y1 - 1977

N2 - 10 Patients with vitamin D resistant hypophosphataemic osteomalacia are described. They had hypophosphataemia with a decreased tubular reabsorption of phosphate, malabsorption of calcium and phosphorus, proximal myopathy and extensive osteomalacic changes on iliac crest bone biopsy. The plasma alkaline phosphatase and urine hydroxyproline, however, were raised in only some of the patients. Treatment with 1α-hydroxyvitamin D3 in high doses rapidly cured the myopathy, increased calcium and phosphorus absorption and retention and healed the osteomalacia. Phosphorus supplements were not required.

AB - 10 Patients with vitamin D resistant hypophosphataemic osteomalacia are described. They had hypophosphataemia with a decreased tubular reabsorption of phosphate, malabsorption of calcium and phosphorus, proximal myopathy and extensive osteomalacic changes on iliac crest bone biopsy. The plasma alkaline phosphatase and urine hydroxyproline, however, were raised in only some of the patients. Treatment with 1α-hydroxyvitamin D3 in high doses rapidly cured the myopathy, increased calcium and phosphorus absorption and retention and healed the osteomalacia. Phosphorus supplements were not required.

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