Vitamin E and risk of type 2 diabetes in the Women's Health Study randomized controlled trial

Simin Liu, I. Min Lee, Yiqing Song, Martin Van Denburgh, Nancy R. Cook, Joann E. Manson, Julie E. Buring

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

We directly assessed the efficacy of vitamin E supplements for primary prevention of type 2 diabetes among apparently healthy women in the Women's Health Study randomized trial. Between 1992 and 2004, 38,716 apparently healthy U.S. women aged ≥45 years and free of diabetes, cancer, and cardiovascular disease were in two randomly assigned intervention groups and received 600 IU of vitamin E (α-tocopherol, n = 19,347) or placebo (n = 19,369) on alternate days. During a median 10-year follow-up, there were 827 cases of incident type 2 diabetes in the vitamin E group and 869 in the placebo group, a nonsignificant 5% risk reduction (relative risk [RR] 0.95 [95% CI 0.87-1.05], P = 0.31). There was no evidence that diabetes risk factors including age, BMI, postmenopausal hormone use, multivitamin use, physical activity, alcohol intake, and smoking status modified the effect of vitamin E on the risk of type 2 diabetes. In a sensitivity analysis taking compliance into account, women in the vitamin E group had an RR of 0.93 (95% CI 0.83-1.04) (P = 0.21) compared with those randomized to placebo. In this large trial with 10-year follow-up, alternate-day doses of 600 IU vitamin E provided no significant benefit for type 2 diabetes in initially healthy women.

Original languageEnglish (US)
Pages (from-to)2856-2862
Number of pages7
JournalDiabetes
Volume55
Issue number10
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Fingerprint

Women's Health
Vitamin E
Type 2 Diabetes Mellitus
Randomized Controlled Trials
Placebos
Tocopherols
Risk Reduction Behavior
Primary Prevention
Compliance
Cardiovascular Diseases
Smoking
Alcohols
Hormones
Exercise
Neoplasms

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Liu, S., Lee, I. M., Song, Y., Van Denburgh, M., Cook, N. R., Manson, J. E., & Buring, J. E. (2006). Vitamin E and risk of type 2 diabetes in the Women's Health Study randomized controlled trial. Diabetes, 55(10), 2856-2862. https://doi.org/10.2337/db06-0456

Vitamin E and risk of type 2 diabetes in the Women's Health Study randomized controlled trial. / Liu, Simin; Lee, I. Min; Song, Yiqing; Van Denburgh, Martin; Cook, Nancy R.; Manson, Joann E.; Buring, Julie E.

In: Diabetes, Vol. 55, No. 10, 01.10.2006, p. 2856-2862.

Research output: Contribution to journalArticle

Liu, S, Lee, IM, Song, Y, Van Denburgh, M, Cook, NR, Manson, JE & Buring, JE 2006, 'Vitamin E and risk of type 2 diabetes in the Women's Health Study randomized controlled trial', Diabetes, vol. 55, no. 10, pp. 2856-2862. https://doi.org/10.2337/db06-0456
Liu, Simin ; Lee, I. Min ; Song, Yiqing ; Van Denburgh, Martin ; Cook, Nancy R. ; Manson, Joann E. ; Buring, Julie E. / Vitamin E and risk of type 2 diabetes in the Women's Health Study randomized controlled trial. In: Diabetes. 2006 ; Vol. 55, No. 10. pp. 2856-2862.
@article{66e59c5e21df4c63911a9e2ff3747e82,
title = "Vitamin E and risk of type 2 diabetes in the Women's Health Study randomized controlled trial",
abstract = "We directly assessed the efficacy of vitamin E supplements for primary prevention of type 2 diabetes among apparently healthy women in the Women's Health Study randomized trial. Between 1992 and 2004, 38,716 apparently healthy U.S. women aged ≥45 years and free of diabetes, cancer, and cardiovascular disease were in two randomly assigned intervention groups and received 600 IU of vitamin E (α-tocopherol, n = 19,347) or placebo (n = 19,369) on alternate days. During a median 10-year follow-up, there were 827 cases of incident type 2 diabetes in the vitamin E group and 869 in the placebo group, a nonsignificant 5{\%} risk reduction (relative risk [RR] 0.95 [95{\%} CI 0.87-1.05], P = 0.31). There was no evidence that diabetes risk factors including age, BMI, postmenopausal hormone use, multivitamin use, physical activity, alcohol intake, and smoking status modified the effect of vitamin E on the risk of type 2 diabetes. In a sensitivity analysis taking compliance into account, women in the vitamin E group had an RR of 0.93 (95{\%} CI 0.83-1.04) (P = 0.21) compared with those randomized to placebo. In this large trial with 10-year follow-up, alternate-day doses of 600 IU vitamin E provided no significant benefit for type 2 diabetes in initially healthy women.",
author = "Simin Liu and Lee, {I. Min} and Yiqing Song and {Van Denburgh}, Martin and Cook, {Nancy R.} and Manson, {Joann E.} and Buring, {Julie E.}",
year = "2006",
month = "10",
day = "1",
doi = "10.2337/db06-0456",
language = "English (US)",
volume = "55",
pages = "2856--2862",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "10",

}

TY - JOUR

T1 - Vitamin E and risk of type 2 diabetes in the Women's Health Study randomized controlled trial

AU - Liu, Simin

AU - Lee, I. Min

AU - Song, Yiqing

AU - Van Denburgh, Martin

AU - Cook, Nancy R.

AU - Manson, Joann E.

AU - Buring, Julie E.

PY - 2006/10/1

Y1 - 2006/10/1

N2 - We directly assessed the efficacy of vitamin E supplements for primary prevention of type 2 diabetes among apparently healthy women in the Women's Health Study randomized trial. Between 1992 and 2004, 38,716 apparently healthy U.S. women aged ≥45 years and free of diabetes, cancer, and cardiovascular disease were in two randomly assigned intervention groups and received 600 IU of vitamin E (α-tocopherol, n = 19,347) or placebo (n = 19,369) on alternate days. During a median 10-year follow-up, there were 827 cases of incident type 2 diabetes in the vitamin E group and 869 in the placebo group, a nonsignificant 5% risk reduction (relative risk [RR] 0.95 [95% CI 0.87-1.05], P = 0.31). There was no evidence that diabetes risk factors including age, BMI, postmenopausal hormone use, multivitamin use, physical activity, alcohol intake, and smoking status modified the effect of vitamin E on the risk of type 2 diabetes. In a sensitivity analysis taking compliance into account, women in the vitamin E group had an RR of 0.93 (95% CI 0.83-1.04) (P = 0.21) compared with those randomized to placebo. In this large trial with 10-year follow-up, alternate-day doses of 600 IU vitamin E provided no significant benefit for type 2 diabetes in initially healthy women.

AB - We directly assessed the efficacy of vitamin E supplements for primary prevention of type 2 diabetes among apparently healthy women in the Women's Health Study randomized trial. Between 1992 and 2004, 38,716 apparently healthy U.S. women aged ≥45 years and free of diabetes, cancer, and cardiovascular disease were in two randomly assigned intervention groups and received 600 IU of vitamin E (α-tocopherol, n = 19,347) or placebo (n = 19,369) on alternate days. During a median 10-year follow-up, there were 827 cases of incident type 2 diabetes in the vitamin E group and 869 in the placebo group, a nonsignificant 5% risk reduction (relative risk [RR] 0.95 [95% CI 0.87-1.05], P = 0.31). There was no evidence that diabetes risk factors including age, BMI, postmenopausal hormone use, multivitamin use, physical activity, alcohol intake, and smoking status modified the effect of vitamin E on the risk of type 2 diabetes. In a sensitivity analysis taking compliance into account, women in the vitamin E group had an RR of 0.93 (95% CI 0.83-1.04) (P = 0.21) compared with those randomized to placebo. In this large trial with 10-year follow-up, alternate-day doses of 600 IU vitamin E provided no significant benefit for type 2 diabetes in initially healthy women.

UR - http://www.scopus.com/inward/record.url?scp=33750889377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750889377&partnerID=8YFLogxK

U2 - 10.2337/db06-0456

DO - 10.2337/db06-0456

M3 - Article

C2 - 17003353

AN - SCOPUS:33750889377

VL - 55

SP - 2856

EP - 2862

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 10

ER -