Vitamin E decreases superoxide anion production by polymorphonuclear leukocytes

W. A. Engle, Mervin Yoder, J. L. Baurley, Pao Lo Yu

Research output: Contribution to journalArticle

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Abstract

Pharmacologic serum levels of vitamin E administered to low birth weight infants predispose them to infectious complications. We studied in vitro the effect of vitamin E, its vehicle and buffer (Krebs Ringers phosphate glucose) on the ability of human polymorphonuclear leukocytes (PMN) to produce superoxide anion, an oxygen radical important for bacterial killing. We found that superoxide anion production after a 5-min exposure to phorbol myristate acetate was significantly decreased in vitamin E-treated PMN (76 ± 15 nM/10<sup>7</sup> PMN) compared to vehicle-treated PMN (289 ± 109 nM/10<sup>7</sup> PMN). We also found that significantly decreased superoxide anion production was associated with 5.0 and 10.0 mg/dl but not with 3.5 mg/dl vitamin E. Our results support the hypothesis that pharmacologic concentrations of vitamin E depress PMN oxidative activity.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalPediatric Research
Volume23
Issue number3
StatePublished - 1988

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Vitamin E
Superoxides
Neutrophils
Low Birth Weight Infant
Tetradecanoylphorbol Acetate
Reactive Oxygen Species
Buffers
Phosphates
Glucose
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Vitamin E decreases superoxide anion production by polymorphonuclear leukocytes. / Engle, W. A.; Yoder, Mervin; Baurley, J. L.; Yu, Pao Lo.

In: Pediatric Research, Vol. 23, No. 3, 1988, p. 245-248.

Research output: Contribution to journalArticle

Engle, WA, Yoder, M, Baurley, JL & Yu, PL 1988, 'Vitamin E decreases superoxide anion production by polymorphonuclear leukocytes', Pediatric Research, vol. 23, no. 3, pp. 245-248.
Engle, W. A. ; Yoder, Mervin ; Baurley, J. L. ; Yu, Pao Lo. / Vitamin E decreases superoxide anion production by polymorphonuclear leukocytes. In: Pediatric Research. 1988 ; Vol. 23, No. 3. pp. 245-248.
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