Vitreous contains a cartilage-related protein

Binh Q. Nguyen, Rose S. Fife

Research output: Contribution to journalArticle

27 Scopus citations


The vitreous is a clear, gel-like mass in the posterior cavity of the eye. Its major components are type II collagen, hyaluronic acid, and water. A small amount of proteoglycan is also present. All of these molecules are found in cartilage as well. We have now identified a non-collagenous protein in bovine and human vitreous samples which has hitherto been found only in hyaline cartilage and fibrocartilage. This protein has a molecular weight of 55000 and subunits of 130000 MW and appears to be a shared cartilage and eye antigen. Its role, if any, in ocular disease associated with rheumatic disorders remains to be determined.

Original languageEnglish (US)
Pages (from-to)375-382
Number of pages8
JournalExperimental eye research
Issue number3
StatePublished - Sep 1986


  • bovine
  • cartilage
  • human
  • non-collagenous proteins
  • vitreous

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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