Vitreous contains a cartilage-related protein

Binh Q. Nguyen, Rose Fife

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The vitreous is a clear, gel-like mass in the posterior cavity of the eye. Its major components are type II collagen, hyaluronic acid, and water. A small amount of proteoglycan is also present. All of these molecules are found in cartilage as well. We have now identified a non-collagenous protein in bovine and human vitreous samples which has hitherto been found only in hyaline cartilage and fibrocartilage. This protein has a molecular weight of 55000 and subunits of 130000 MW and appears to be a shared cartilage and eye antigen. Its role, if any, in ocular disease associated with rheumatic disorders remains to be determined.

Original languageEnglish
Pages (from-to)375-382
Number of pages8
JournalExperimental Eye Research
Volume43
Issue number3
DOIs
StatePublished - 1986

Fingerprint

Cartilage
Fibrocartilage
Hyaline Cartilage
Collagen Type II
Eye Diseases
Proteoglycans
Hyaluronic Acid
Proteins
Molecular Weight
Gels
Antigens
Water

Keywords

  • bovine
  • cartilage
  • human
  • non-collagenous proteins
  • vitreous

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Vitreous contains a cartilage-related protein. / Nguyen, Binh Q.; Fife, Rose.

In: Experimental Eye Research, Vol. 43, No. 3, 1986, p. 375-382.

Research output: Contribution to journalArticle

Nguyen, Binh Q. ; Fife, Rose. / Vitreous contains a cartilage-related protein. In: Experimental Eye Research. 1986 ; Vol. 43, No. 3. pp. 375-382.
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