VmrA, a member of a novel class of Na+-coupled multidrug efflux pumps from Vibrio parahaemolyticus

J. Chen, Y. Morita, Nazmul Huda, T. Kuroda, T. Mizushima, T. Tsuchiya

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Gene vmrA, cloned from Vibrio parahaemolyticus, made Escherichia coli resistant to 4′,6-diamino-2-phenylindol, tetraphenylphosphonium chloride, acriflavine, and ethidium bromide. VmrA belongs to the DinF branch of MATE family efflux transporters. VmrA catalyzed acriflavine efflux and showed Na+/drug transporter activity because the addition of tetraphenylphosphonium to Na+-loaded cells caused Na+ efflux.

Original languageEnglish (US)
Pages (from-to)572-576
Number of pages5
JournalJournal of Bacteriology
Volume184
Issue number2
DOIs
StatePublished - Jan 12 2002
Externally publishedYes

Fingerprint

Acriflavine
Vibrio parahaemolyticus
Ethidium
Escherichia coli
Pharmaceutical Preparations
Genes
tetraphenylphosphonium

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

VmrA, a member of a novel class of Na+-coupled multidrug efflux pumps from Vibrio parahaemolyticus. / Chen, J.; Morita, Y.; Huda, Nazmul; Kuroda, T.; Mizushima, T.; Tsuchiya, T.

In: Journal of Bacteriology, Vol. 184, No. 2, 12.01.2002, p. 572-576.

Research output: Contribution to journalArticle

Chen, J. ; Morita, Y. ; Huda, Nazmul ; Kuroda, T. ; Mizushima, T. ; Tsuchiya, T. / VmrA, a member of a novel class of Na+-coupled multidrug efflux pumps from Vibrio parahaemolyticus. In: Journal of Bacteriology. 2002 ; Vol. 184, No. 2. pp. 572-576.
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AU - Mizushima, T.

AU - Tsuchiya, T.

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