Voltage-gated calcium channel current in coronary arterial smooth muscle cells from alloxan diabetic pigs

Michael Sturek, C. Y. Liu, G. M. Dick

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Previous studies have shown that high glucose concentrations alter membrane cation permeability and contractile responses of vascular smooth muscle. We determined whether 12 weeks of diabetes alters Ca influx via voltage-gated Ca channels (VGCC). Whole-cell VGCC currents were measured with the perforated-patch technique in epicardial coronary smooth musde cells from control and diabetic pigs. Cells from both groups exhibited only L-type Ca current. Current density was smaller in cells from diabetic pigs (maximal density: 1.93 ±0.42 pA/pF vs. 1.18±0.15 pA/pF, p

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

alloxan
Alloxan
calcium channels
Calcium Channels
smooth muscle
myocytes
Smooth Muscle Myocytes
Muscle
Swine
Cells
swine
Electric potential
Medical problems
Cations
Current density
cells
Membranes
Glucose
Vascular Smooth Muscle
blood vessels

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Voltage-gated calcium channel current in coronary arterial smooth muscle cells from alloxan diabetic pigs. / Sturek, Michael; Liu, C. Y.; Dick, G. M.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

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