Voluntary wheel running has beneficial effects in a rat model of CKD-mineral bone disorder (CKD-MBD)

Keith G. Avin, Matthew R. Allen, Neal X. Chen, Shruthi Srinivasan, Kalisha D. O'Neill, Ashley D. Troutman, Garrison Mast, Elizabeth A. Swallow, Mary Beth Brown, Joseph M. Wallace, Teresa A. Zimmers, Stuart J. Warden, Sharon M. Moe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background Reduced bone and muscle health in individuals with CKD contributes to their higher rates of morbidity and mortality. Methods We tested the hypothesis that voluntary wheel running would improve musculoskeletal health in a CKD rat model. Rats with spontaneous progressive cystic kidney disease (Cy/1 IU) and normal littermates (NL) were given access to a voluntary running wheel or standard cage conditions for 10 weeks starting at 25 weeks of age when the rats with kidney disease had reached stage 2-3 of CKD. We then measured the effects of wheel running on serum biochemistry, tissue weight, voluntary grip strength, maximal aerobic capacity (VO2max), body composition and bone micro-CT and mechanics. Results Wheel running improved serum biochemistry with decreased creatinine, phosphorous, and parathyroid hormone in the ratswith CKD. It improvedmuscle strength, increased time-to-fatigue (for VO2max), reduced cortical porosity and improved bonemicroarchitecture. The CKDrats with voluntarywheel access also had reduced kidney cystic weight and reduced left ventricular mass index. Conclusions Voluntary wheel running resulted in multiple beneficial systemic effects in rats with CKD and improved their physical function. Studies examining exercise interventions in patients with CKD are warranted.

Original languageEnglish (US)
Pages (from-to)1898-1909
Number of pages12
JournalJournal of the American Society of Nephrology
Volume30
Issue number10
DOIs
StatePublished - Jan 1 2019

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Running
Minerals
Bone and Bones
Cystic Kidney Diseases
Biochemistry
Weights and Measures
Porosity
Health
Kidney Diseases
Hand Strength
Body Composition
Mechanics
Parathyroid Hormone
Serum
Fatigue
Creatinine
Exercise
Morbidity
Muscles
Mortality

ASJC Scopus subject areas

  • Nephrology

Cite this

Voluntary wheel running has beneficial effects in a rat model of CKD-mineral bone disorder (CKD-MBD). / Avin, Keith G.; Allen, Matthew R.; Chen, Neal X.; Srinivasan, Shruthi; O'Neill, Kalisha D.; Troutman, Ashley D.; Mast, Garrison; Swallow, Elizabeth A.; Brown, Mary Beth; Wallace, Joseph M.; Zimmers, Teresa A.; Warden, Stuart J.; Moe, Sharon M.

In: Journal of the American Society of Nephrology, Vol. 30, No. 10, 01.01.2019, p. 1898-1909.

Research output: Contribution to journalArticle

Avin, KG, Allen, MR, Chen, NX, Srinivasan, S, O'Neill, KD, Troutman, AD, Mast, G, Swallow, EA, Brown, MB, Wallace, JM, Zimmers, TA, Warden, SJ & Moe, SM 2019, 'Voluntary wheel running has beneficial effects in a rat model of CKD-mineral bone disorder (CKD-MBD)', Journal of the American Society of Nephrology, vol. 30, no. 10, pp. 1898-1909. https://doi.org/10.1681/ASN.2019040349
Avin, Keith G. ; Allen, Matthew R. ; Chen, Neal X. ; Srinivasan, Shruthi ; O'Neill, Kalisha D. ; Troutman, Ashley D. ; Mast, Garrison ; Swallow, Elizabeth A. ; Brown, Mary Beth ; Wallace, Joseph M. ; Zimmers, Teresa A. ; Warden, Stuart J. ; Moe, Sharon M. / Voluntary wheel running has beneficial effects in a rat model of CKD-mineral bone disorder (CKD-MBD). In: Journal of the American Society of Nephrology. 2019 ; Vol. 30, No. 10. pp. 1898-1909.
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N2 - Background Reduced bone and muscle health in individuals with CKD contributes to their higher rates of morbidity and mortality. Methods We tested the hypothesis that voluntary wheel running would improve musculoskeletal health in a CKD rat model. Rats with spontaneous progressive cystic kidney disease (Cy/1 IU) and normal littermates (NL) were given access to a voluntary running wheel or standard cage conditions for 10 weeks starting at 25 weeks of age when the rats with kidney disease had reached stage 2-3 of CKD. We then measured the effects of wheel running on serum biochemistry, tissue weight, voluntary grip strength, maximal aerobic capacity (VO2max), body composition and bone micro-CT and mechanics. Results Wheel running improved serum biochemistry with decreased creatinine, phosphorous, and parathyroid hormone in the ratswith CKD. It improvedmuscle strength, increased time-to-fatigue (for VO2max), reduced cortical porosity and improved bonemicroarchitecture. The CKDrats with voluntarywheel access also had reduced kidney cystic weight and reduced left ventricular mass index. Conclusions Voluntary wheel running resulted in multiple beneficial systemic effects in rats with CKD and improved their physical function. Studies examining exercise interventions in patients with CKD are warranted.

AB - Background Reduced bone and muscle health in individuals with CKD contributes to their higher rates of morbidity and mortality. Methods We tested the hypothesis that voluntary wheel running would improve musculoskeletal health in a CKD rat model. Rats with spontaneous progressive cystic kidney disease (Cy/1 IU) and normal littermates (NL) were given access to a voluntary running wheel or standard cage conditions for 10 weeks starting at 25 weeks of age when the rats with kidney disease had reached stage 2-3 of CKD. We then measured the effects of wheel running on serum biochemistry, tissue weight, voluntary grip strength, maximal aerobic capacity (VO2max), body composition and bone micro-CT and mechanics. Results Wheel running improved serum biochemistry with decreased creatinine, phosphorous, and parathyroid hormone in the ratswith CKD. It improvedmuscle strength, increased time-to-fatigue (for VO2max), reduced cortical porosity and improved bonemicroarchitecture. The CKDrats with voluntarywheel access also had reduced kidney cystic weight and reduced left ventricular mass index. Conclusions Voluntary wheel running resulted in multiple beneficial systemic effects in rats with CKD and improved their physical function. Studies examining exercise interventions in patients with CKD are warranted.

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