Waist circumference and metabolic syndrome: The risk for silent coronary artery disease in males

Kairav P. Vakil, Saurabh Malhotra, Stephen Sawada, Steffanie R. Campbell, Sameh Sayfo, Masoor Kamalesh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Waist circumference (WC) is a component used to define metabolic syndrome. However, its role as an independent predictor of silent coronary artery disease (CAD), above its contribution to metabolic syndrome, remains unknown. Methods: Male veterans without known CAD, undergoing cardiac stress testing for indications other than typical angina or its equivalent, were evaluated for the presence of silent CAD. High WC and metabolic syndrome were defined per the revised National Cholesterol Education Program (NCEP-R) and the International Diabetes Federation (IDF) criteria. Results: Data on 1,071 patients (age 61±11 years) were analyzed retrospectively. On multivariable logistic regression analysis [odds ratio (OR), 95% confidence interval (CI), P value), a WC ≥94cm (1.42, 1.04-1.93; P=0.026), metabolic syndrome by NCEP-R (1.73, 1.29-2.33; P<0.0001), and metabolic syndrome by IDF (1.57, 1.17-2.11; P=0.003) were independent predictors of silent CAD. When comparing patients meeting criteria for metabolic syndrome defined by either NCEP-R or IDF, the prevalence of silent CAD was not statistically different (P=0.86). The prevalence of silent CAD associated with a high WC was not inferior to that seen between silent CAD and metabolic syndrome as defined by either criterion. Last, among patients with metabolic syndrome defined by NCEP-R, those with a high WC as a defining component of metabolic syndrome had a higher prevalence of silent CAD (30% vs. 20%; P=0.026). Conclusion: A WC ≥94cm in males is independently associated with an increased prevalence of silent CAD. In patients with metabolic syndrome, this prevalence is increased by the presence of high WC.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalMetabolic Syndrome and Related Disorders
Volume10
Issue number3
DOIs
StatePublished - Jun 1 2012

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Waist Circumference
Coronary Artery Disease
Cholesterol
Education
Veterans
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Waist circumference and metabolic syndrome : The risk for silent coronary artery disease in males. / Vakil, Kairav P.; Malhotra, Saurabh; Sawada, Stephen; Campbell, Steffanie R.; Sayfo, Sameh; Kamalesh, Masoor.

In: Metabolic Syndrome and Related Disorders, Vol. 10, No. 3, 01.06.2012, p. 225-231.

Research output: Contribution to journalArticle

Vakil, Kairav P. ; Malhotra, Saurabh ; Sawada, Stephen ; Campbell, Steffanie R. ; Sayfo, Sameh ; Kamalesh, Masoor. / Waist circumference and metabolic syndrome : The risk for silent coronary artery disease in males. In: Metabolic Syndrome and Related Disorders. 2012 ; Vol. 10, No. 3. pp. 225-231.
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abstract = "Background: Waist circumference (WC) is a component used to define metabolic syndrome. However, its role as an independent predictor of silent coronary artery disease (CAD), above its contribution to metabolic syndrome, remains unknown. Methods: Male veterans without known CAD, undergoing cardiac stress testing for indications other than typical angina or its equivalent, were evaluated for the presence of silent CAD. High WC and metabolic syndrome were defined per the revised National Cholesterol Education Program (NCEP-R) and the International Diabetes Federation (IDF) criteria. Results: Data on 1,071 patients (age 61±11 years) were analyzed retrospectively. On multivariable logistic regression analysis [odds ratio (OR), 95{\%} confidence interval (CI), P value), a WC ≥94cm (1.42, 1.04-1.93; P=0.026), metabolic syndrome by NCEP-R (1.73, 1.29-2.33; P<0.0001), and metabolic syndrome by IDF (1.57, 1.17-2.11; P=0.003) were independent predictors of silent CAD. When comparing patients meeting criteria for metabolic syndrome defined by either NCEP-R or IDF, the prevalence of silent CAD was not statistically different (P=0.86). The prevalence of silent CAD associated with a high WC was not inferior to that seen between silent CAD and metabolic syndrome as defined by either criterion. Last, among patients with metabolic syndrome defined by NCEP-R, those with a high WC as a defining component of metabolic syndrome had a higher prevalence of silent CAD (30{\%} vs. 20{\%}; P=0.026). Conclusion: A WC ≥94cm in males is independently associated with an increased prevalence of silent CAD. In patients with metabolic syndrome, this prevalence is increased by the presence of high WC.",
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