Walk the line: The role of ubiquitin in regulating transcription in myocytes

Vidyani Suryadevara, Monte S. Willis

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The ubiquitin-proteasome offers novel targets for potential therapies with their specific activities and tissue localization. Recently, the expansion of our understanding of how ubiquitin ligases (E3s) specifically regulate transcription has demonstrated their roles in skeletal muscle, complementing their roles in protein quality control and protein degradation. This review focuses on skeletal muscle E3s that regulate transcription factors critical to myogenesis and the maintenance of skeletal muscle wasting diseases.

Original languageEnglish (US)
Pages (from-to)327-340
Number of pages14
JournalPhysiology
Volume34
Issue number5
DOIs
StatePublished - Sep 2019

Keywords

  • Atrophy
  • Differentiation
  • Skeletal muscle
  • Transcription factors
  • Ubiquitin ligase

ASJC Scopus subject areas

  • Physiology

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