Wall remodeling during luminal expansion of mesenteric arterial collaterals in the rat

Joseph L. Unthank, Steven W. Fath, Harold M. Burkhart, Scott C. Miller, Michael Dalsing

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Wall remodeling associated with rapid luminal enlargement of collateral mesenteric arteries in rats was investigated 1 and 4 weeks after creation of a collateral pathway by ligating three to four sequential arteries. Paired observations were made of inner diameters of collateral and normal arteries in the same animals. Arterial blood flow was measured at the final observation. Sections of arteries were processed for morphological measurements. After 4 weeks, inner arterial diameter was increased more at the beginning (63±6%) than the end (25±9%) of the collateral pathway. At 1 and 4 weeks, respectively, cross-sectional areas of collateral relative to normal arteries were increased by 46±5% and 59±13% (lumen), 55±8% and 65±14% (media), and 89±18% and 60±31% (intima). The wall expansion during luminal enlargement resulted in a normal medial thickness:luminal radius relationship. At 1 week postligation, wall shear rate remained elevated and endothelial but not smooth muscle hyperplasia had occurred (intimal nuclei: 40±1.7 collateral versus 24±3.0 normal; medial nuclei: 42±6.8 collateral versus 37±2.1 normal). At 4 weeks, wall shear rate in collaterals was similar to normal arteries, and smooth muscle hyperplasia had taken place (medial nuclei: 84±9.4 collateral versus 44±4.7 normal). The data demonstrate that wall expansion associated with rapid luminal enlargement of these collaterals involves hyperplasia of both endothelial and smooth muscle cells; however, smooth muscle proliferation does not occur until after wall shear rate is reduced. The specific cellular adaptations that occur during collateral development may depend on the level of wall shear and shear- dependent modulation of endothelial growth factors.

Original languageEnglish
Pages (from-to)1015-1023
Number of pages9
JournalCirculation Research
Volume79
Issue number5
StatePublished - 1996

Fingerprint

Arteries
Hyperplasia
Smooth Muscle
Endothelial Growth Factors
Tunica Intima
Mesenteric Arteries
Smooth Muscle Myocytes
Observation

Keywords

  • arterial growth
  • endothelium
  • hyperplasia
  • vascular smooth muscle
  • wall remodeling

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Unthank, J. L., Fath, S. W., Burkhart, H. M., Miller, S. C., & Dalsing, M. (1996). Wall remodeling during luminal expansion of mesenteric arterial collaterals in the rat. Circulation Research, 79(5), 1015-1023.

Wall remodeling during luminal expansion of mesenteric arterial collaterals in the rat. / Unthank, Joseph L.; Fath, Steven W.; Burkhart, Harold M.; Miller, Scott C.; Dalsing, Michael.

In: Circulation Research, Vol. 79, No. 5, 1996, p. 1015-1023.

Research output: Contribution to journalArticle

Unthank, JL, Fath, SW, Burkhart, HM, Miller, SC & Dalsing, M 1996, 'Wall remodeling during luminal expansion of mesenteric arterial collaterals in the rat', Circulation Research, vol. 79, no. 5, pp. 1015-1023.
Unthank, Joseph L. ; Fath, Steven W. ; Burkhart, Harold M. ; Miller, Scott C. ; Dalsing, Michael. / Wall remodeling during luminal expansion of mesenteric arterial collaterals in the rat. In: Circulation Research. 1996 ; Vol. 79, No. 5. pp. 1015-1023.
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